Creatine is a compound naturally present in the human organism. Perhaps, it is known mostly for its anabolic effects – creatine supplementation leads to an increase of muscle mass, strength, and regenerative capacity, especially after workout. What is more, it stimulates the activity of mitochondria and supports the nervous system, increasing levels of energy and motivation.
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Creatine | PharmaCreatine™
Properties: Creatine is secreted within the human organism. However, there are times when its density in the body does not meet the demands. This is when the supplementation comes into play. Products based on creatine are especially popular among sportsmen – professionals and newbies alike. This is because the most important function of creatine is the regeneration of ATP molecules in the organism. These molecules are the main source of energy for our cells. By improving the recycling of ATP, creatine allows us to work out longer, because it provides more “fuel” required for the body. Nevertheless, this is not the only mechanism which makes creatine so useful for sportsmen. As it turns out, this compound can also increase the strength of the muscles – its anabolic effect upregulates the synthesis of proteins that build muscle structure. Simultaneously, it limits their decomposition, therefore protecting the muscles from losing their strength and mass – especially after exhausting training. On top of that, it supports the regeneration of muscle cells by stimulating the secretion of hormones that are responsible for their restoration and accelerate their growth. Noteworthy, creatine reduces the production of lactic acid that causes so-called “sore muscles”. This is especially important because this unpleasant feeling after training can successfully demotivate us and make the next session much tougher. Many experienced coaches agree that creatine supplementation is a perfect method to increase body mass necessary to expand muscles. This property of creatine has been thoroughly researched . It has been proven that this natural anabolic can indeed help to build up muscle mass.
Even if creatine is most often supplemented by sportsmen, by no means people who are less fond of working out can also benefit from it! Anabolic properties of this compound will support everyone, especially in tough circumstances when the organism requires more energy. The supplementation of creatine will bring about faster regeneration of the muscles, increase of their strength, and the improvement of stamina.
Occurrence: Although some amounts of creatine are produced within the human organism, this compound is predominantly delivered with food. Its sources are mainly meat: beef, poultry, rabbit, beef and pork heart as well as fish: cod, herring, salmon, and tuna. Milk and dairy products contain only a small amount of creatine.
Biochemistry: Chemically speaking, creatine is classified as a peptide. Its molecule is produced from the combination of L-arginine, methionine, and glycine molecules. Creatine is synthesized in the liver, kidneys and pancreas. In the organism, it supports the process of protein synthesis, mainly by anabolic and anti catabolic reactions. Therefore, it accelerates the growth of muscle mass. Moreover, creatine plays the key role in the renewal of ATP – the fundamental energy source of the organism. Under the influence of the enzyme creatine phosphokinase, creatine is phosphorylated. As a result of a chemical reaction, phosphocreatine is formed. This substance is a substrate necessary for ATP resynthesis. As a supplement, creatine comes in various forms, the most popular of which are creatine monohydrate and creatine malate. They differ in their chemical structure – monohydrate is a combination of water molecules with creatine, while malate is formed by combining monohydrate with malic acid.
Fun fact: Creatine was discovered in 1832 during the investigation of substances present in the skeletal muscles. This is where its name comes from – in Greek “kreas” means “meat”.
How does Creatine | PharmaCreatine™ work?
Increases muscle mass and strength: Research evidence proves that creatine can increase the diameter of muscle fibers even by 10%. This effect is related to the water inflow, but not only. For these cells creatine is the source of energy that is used predominantly during exercises of high intensity. It has anabolic effect – it decreases the ratio of protein oxygenation – thus, leads to the increase of the muscle mass. Therefore, creatine supplementation improves their functioning and strength. Results of clinical trials confirm that the supplementation of creatine before training reduces the production of lactic acid within muscles which prevents them from soreness.
Improves energy level: Creatine, in its phosphorylated form, is used to store energy necessary for many chemical processes. Phosphocreatine takes part in the production of ATP which is the main source of energy in the cells. The reaction with phosphocreatine occurs in the first 2-7 seconds after an increase in energy demand, due to, for example, physical or neural exertion. Additionally, creatine increases the secretion of dopamine – the neurotransmitter responsible for feeling energized and motivated. In combination, these two properties significantly help to soothe chronic fatigue syndrome.
Increases body mass: Research results show that creatine helps to build body mass. Partially, this is because this peptide increases water inflow to the muscle tissue. Additional mass can occur even after a week of supplementation, provided that the dose is high (20 g daily). Creatine increases body mass also in the long run. Importantly, this effect does not arise from the increase of fatty tissue, but from the improvement of muscle development. For this reason creatine is a perfect workout supplement for sportsmen but also for the elderly people facing the issue of muscle degeneration.
Improves regeneration: Creatine not only helps to perform an intense workout routine but also supports the regeneration of the organism afterwards. Results of clinical trials show that even a single dose leads to a significant increase of the growth hormone secretion within the next six hours. This hormone stimulates the regeneration of tissue breakages during workout. What is more, creatine protects the DNA from free radicals. One of their effects is the reduction of cellular ATP resources that creatine can rebuild. This peptide also has a positive effect on bone health: it helps to increase their mineral density and strength by over 12%.
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