Hordenine | PharmaHordenine™

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Hordenine is a compound from a group of plant-derived alkaloids. It promotes the activity of dopamine thereby increasing energy and motivation. Hordenine is also often used in order to enhance physical performance during workout or any intensive effort. Moreover, it accelerates metabolism and reduces appetite which makes it a perfect support in any weight-loss endeavor.


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Hordenine | PharmaHordenine™

Properties: Hordenine is a natural compound of an unusual origin. It is present in many grains, but its highest density is found in barley. Some exotic plants, such as bitter orange or cacti, also contain significant amounts of this substance. Interestingly, hordenine’s amazing effects were first observed in racing horses. Racing horses that were on a barley-based diet turned out to be more successful – they had better scores and their organisms were more efficient. These effects were so strong that hordenine became forbidden by horse racing federations to prevent a bias in the race results. However, hordenine was not forgotten and entered the market of supplements designed for humans. It turned out that its administration brings about many benefits, even in moderate doses. 

The main advantage of hordenine supplementation is that it significantly increases the energy level. Because of its influence on dopamine system activity, hordenine benefits the subjective feeling of motivation and drive to action. Since dopamine is one of the main excitatory neurotransmitters, its higher level limits tiredness and sleepiness. It is also connected with the ability to focus. The increase of dopamine activity promotes concentration while simultaneously allowing efficient multitasking. In sum, hordenine supplementation ensures enough energy resources to meet everyday challenges with ease.  Furthermore, it has been demonstrated that this alkaloid supports weight loss. This is due to hordenine’s influence on the metabolic processes that occur on the cellular level. As it turns out, hordenine accelerates the metabolism of fats and thereby enables faster body weight reduction. Therefore, its supplementation makes losing extra pounds much lighter.  

That’s not all! Hordenine can also improve physical performance. It supports the activity of adrenaline and noradrenaline neurotransmitters, which prepare the body for intense effort. No wonder that horses fed with hordenine-rich barley had better scores than horses on a regular diet! This effect is sometimes exploited by sportsmen, who administer hordenine before workout, in order to improve their own efficiency.  Hordenine is interesting especially when we are in need of extra energy resources, aim to strengthen concentration, or to prepare for intense physical work.

Occurrence: Hordenine occurs naturally in dozens of plant species, including galanthus (Galanthus sp.), coastal pancratium (Pancratium maritimum), or soaring polyalthia (Polyalthia longifolia). The greatest amounts of hordenine are produced by cacti. Its richest source is Echinopsis candicans cactus (previously called Trichocereus candicans) which contains around 0,5–5,0% of this compound. Hordenine is also present in seedlings of grains such as: common barley (Hordeum vulgare), millet (Panicum miliaceum), milo (Sorgo vulgare). It can also be found in fruits of bitter orange (Citrus aurantium).

Biochemistry: Hordenine (N, N-dimethylthyramine, anhaline) is an organic chemical compound that belongs to the plant alkaloids class. Its chemical structure resembles amino acid tyramine, although it is produced from another amino acid – L-tyrosine. As it contains both basic (amino) and acidic (phenol) groups, it is classified as an amphoteric compound. It crosses the blood-brain barrier easily. Hordenine stimulates the activity of dopamine, adrenaline, and acetylcholine. Additionally, it accelerates the metabolism of fats.

Fun fact: Barley malt is often used in beer brewing. Therefore, hordenine can also be found in beer. Beer contains about 12–24 mg/l hordenine, its wort (a fluid extracted during beer brewing) around 11–13 mg/l, and the malt itself around 67 μg/g.

How does Hordenine | PharmaHordenine™ work?

Increases energy level: Dopamine is an important excitatory neurotransmitter. Sometimes it is even said that dopamine in the brain works just like fuel in a car. Its optimal activity determines the appropriate level of energy and motivation. When its activity drops, a surge of exhaustion and sleepiness takes place. Hordenine efficiently prevents this drop. Research evidence indicates that this compound works as an inhibitor of monoamine oxidase B (MAO-B), i.e. an enzyme responsible for dopamine decomposition. In other words, hordenine allows dopamine molecules to remain present in synaptic clefts and influence target neurons longer. In this way, hordenine helps to combat tiredness and maintain the drive to action.

Reduces body weight: Fat tissue generally stores the energy for the body. This energy is activated under the influence of noradrenaline. Research evidence confirmed that this neurotransmitter’s activity increases after hordenine administration. It turns out that hordenine accelerates the metabolism of fats and therefore allows to burn more calories without increasing the intensity of workout. Additionally, higher amounts of noradrenaline in the central nervous system help to decrease the appetite. Therefore, it becomes much easier to maintain regular meal times and limit snacking habits.

Supports attention: Dopamine is important in many areas, not only to maintain optimal energy levels. This neurotransmitter also determines the ability to focus attention on a specific object or task. Its activity is crucial for so-called multitasking, which requires flexible redeployment of attentional resources from one subject to another. It is proven that hordenine increases the activity of dopamine. Therefore, it strengthens the concentration and increases motivation. Sportsmen often take advantage of these properties to better focus on their training routine.

Improves physical performance: The subjective feeling of energy depends on the balanced activity of dopamine, adrenaline, and noradrenaline. The two latter ones are also functioning as hormones. The increase of their secretion leads to improvement of muscle tone, the speed of heartbeat, and the blood circulation, thereby providing optimal oxygenation and nutrition to all bodily tissues. Hordenine supplementation improves physical performance because it actually increases the activity of dopamine, adrenaline, and noradrenaline.

Hordenine | PharmaHordenine™ product specification


  • powdered raw ingredient
  • hordenine >99%; pharmaceutical quality
  • steel measuring tool 0.10 ml ~ 33 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

How to use Hordenine | PharmaHordenine™?


  • 25 – 50 mg
  • 1 – 2
  • without food
  • during the day / before workout
  • 3-4 days a week

How to stack Hordenine | PharmaHordenine™?

To increase energy level:
To facilitate weight loss:
To support focus:
To improve physical endurance:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.