Cissus extract 20:1 | Cissus quadrangularis

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Cissus is an herb commonly used in natural medicine of the Far East. It brings numerous health benefits, but most importantly helps to take care of bones and joints – improving their condition and regeneration. It is also a valuable support for those who want to lose weight. And because cissus regulates serotonin and GABA levels, it increases stress resilience and reduces pain.


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Cissus extract 20:1 | Cissus quadrangularis

Properties: In India, cissus quadrilateral goes by the name “bone healer” because for centuries it has been used in bone fractures therapy. Today, we know for sure that C.quadrangularis does not only help to rebuild the bone tissue after damage, but also prevents its loss – which might be useful in osteoporosis prophylaxis. What else can this strange plant offer? 

For now let’s stick with the motor apparatus. Cissus efficiently supports the work of osteogenic cells, which produce collagen too. This protein is needed not only to construct bones. Its increased availability benefits the condition of the joints and, naturally, the skin. This effect was confirmed in an experiment run with participation of sportsmen who suffered from joint aches after workouts. In their case cissus turned out to be an excellent remedy – its supplementation significantly decreased the unpleasant sensations. Noteworthy, that result could be also caused by analgesic properties of this plant, which are often compared to aspirin. Thus, most likely the combined influence was observed. 

Here, it is worth mentioning that C.quadrangularis extract helps to maintain physical fitness too. Clinical trials confirmed that it supports weight loss. Results indicated a 10% decrease of body weight on average across a few weeks. Thus, cissus excellently accompanies the diet of those people who are physically active and want their training to bring results faster, as well as for the elderly who suffer from joint aches or fight osteoporosis.  

Until now our attention was focused on the body in the macroscopic scale. However, it is important to remember that cissus works also in more subtle ways. This is because it contains a wide range of active compounds, which benefit the entire organism. Among most known are: provitamin A, vitamins C and E, quercetin, caffeine, resveratrol –  to name a few. This last one is often called “the youth elixir”, because it actually prolongs the lifespan of laboratory animals. In our case, one of the most prominent effects of C.quadrangularis supplementation is the decrease of triglycerides and “bad” cholesterol levels, which can undoubtedly extend our lives.     

Speaking of long life… For sure there are many ways to obtain it. Nevertheless, in the common core of all of them lie the inner peace, smile, and positive thinking. In sum – less stress. As it turned out, modern research has proven that supplementation of  C.quadrangularis can also help us to deal with the unpleasant aspects of everyday life. This is because cissus regulates the secretion of GABA neurotransmitter, which in general induces relaxation. Thus, if your neck muscles are often stiff, it might be a sign that it’s the right time to begin cissus supplementation. 

Occurrence: Cissus quadrangularis is a plant from the grapevine family (Vitaceae). It grows in tropical and southern parts of Africa and in Asia, from the Arabian Peninsula, through the Indian Peninsula, to the Indochinese Peninsula and the Philippines. In contrast to other species of this genus it is a succulent. This means that its tissues evolved specifically to store water, thus it can grow even in dry soils low in nutrients.  

It is a creeping plant. Its stem forms segments 8-10 cm long and 1.5 cm wide, and has a quadrilateral shape in cross-section, hence the species name “quadrilateral”. The shape of these thickened shoots has made this plant also known as the “devil’s backbone”. C.quadrangularis has thin, bright green leaves. Their lamina can take various shapes: from ovoid or heart-shaped to three-lobed. During the hot season they are shed due to unfavorable conditions. The flowers with four white or pink petals are approx. 2 mm long. They are gathered in small, umbel-like inflorescences with peduncles up to 2.5 cm long. They produce red, single-seed berries that are 6-10 mm wide and very sour.

Traditional Asian medicine has admired this plant for centuries. Its shoots and roots have been applied both fresh or powdered either internally or externally. In Ayurveda, they are considered to stimulate the healing of fractures as well as damaged ligaments and tendons. In other Far East medical systems cissus has been used to cure sexually transmitted diseases, indigestion, food poisoning, menstrual irregularities, back aches and osteoporosis.

Biochemistry: Cissus quadrangularis contains a plethora of biologically active compounds.  Among them are carotenoids (along with provitamin A), triterpene compounds, ascorbic acid (vitamin C), tocopherol (vitamin E), flavonoids, phytosterols, phytoestrogens, quercetin, resveratrol and caffeine. This plant also contains minerals, including calcium.

Fun fact: The most valued activity of cissus quadrangularis is the acceleration of bone fusion after fractures. This is highlighted by its traditional Indian names: “Harjor” (meaning “bone healer”) and “Asthi Shrinkhala” (which stands for “the one who protects the bones”).

How does Cissus extract 20:1 | Cissus quadrangularis work?

Benefits joints and bones: The positive impact of cissus on bones has been exploited since centuries by traditional medical systems of Asian countries. Modern research evidence confirms this effect fully. Active compounds present in this plant promote the multiplication of osteoblasts, i.e. bone-forming cells. It has been proven that they benefit the healing of fractures and prevent the loss of bone tissue. Moreover, they stimulate the production of collagen – a protein that is like a net supporting the bone cells. Increased amounts of collagen benefit the joints too, since their cartilage is made up largely of this protein.

Increases resistance to pain and stress: Cissus quadrangularis has analgesic properties similar to those of aspirin or even stronger. These results have been confirmed in clinical trials with athletes who felt joint pain because of intensive workout routines. By supplementing cissus they were able to soothe their pain. This effect might have to do with the fact that this herb increases serotonin density in the blood. Cissus also stimulates the activity of GABA – the neurotransmitter that helps to deal with stress. Hence, it effectively reduces anxiety and improves stress resilience.

Reduces body mass: It has been proven that this herb might be effective in treating metabolic syndrome. One of the parts that make this syndrome is the excessive amount of fat tissue, especially in the abdominal area. Cissus effectively helps to reduce that kind of tissue. During clinical trials only a few weeks of supplementation with cissus extract helped to reduce weight by roughly 10% and reduce waist size. The scientists have also observed that the participants of the tests had lowered glucose levels in blood, lower cholesterol (particularly the “bad” LDL faction) and triglycerides. It is very likely that these effects come from the fact that cissus reduces fat absorption from the food. It also increases serotonin concentration which actually might be helpful to induce the feeling of satiety.

Strengthens the liver: Research evidence proves that the extract from cissus has hepatoprotective properties. In other words, it protects the cells of the liver from adversarial influence of some chemicals. Moreover, it helps to decrease “bad” LDL cholesterol and triglycerides levels, and increases the concentration of “good” HDL cholesterol. It prevents fatty liver, especially if you eat high-fat foods. Importantly, it is proven that cissus supports dealing with metabolic syndrome. One of its symptoms is the extra amount of lipid tissue, especially in the belly area. Multiple studies indicated that supplementation with this herb successfully reduces this surplus. Clinical trials demonstrated that in just a few weeks the body mass decreases by 10% on average.

Cissus extract 20:1 | Cissus quadrangularis product specification


  • powdered raw ingredient
  • extract 20:1 from Cissus quadrangularis
  • steel measuring tool 0.60 ml ~ 475 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

How to use Cissus extract 20:1 | Cissus quadrangularis?


  • 400 – 800 mg
  • 1 – 3
  • with or without food
  • during the day
  • 12 weeks of using – 4 weeks of break

How to stack Cissus extract 20:1 | Cissus quadrangularis?

To improve the condition of bones and joints:
To support regeneration after workout:
To facilitate weight reduction:
To improve natural immunity:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.