CDP-Choline | Citicoline

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CDP-Choline is one of the most absorbable sources of choline. By stimulating the production of acetylcholine it supports the process of learning and enhances creative application of knowledge. Besides that, supplementation with CDP-choline raises the density of ATP in the nervous cells and increases the energy level. Also, by regulating the activity of dopamine, it boosts motivation.


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CDP-Choline | Citicoline

Properties: CDP-choline was discovered in the middle of the 20th century and since then its properties have been extensively researched. Researchers investigated its potential to enhance the functioning of the central nervous system. There were many studies that gave us promising results. 

First of all, CDP-choline is easy to absorb – when administered orally its digestibility reaches 95%, which makes it one of the best sources of choline. Moreover, it can cross the blood-brain barrier and thus quickly and efficiently deliver the material to produce acetylcholine. Because of that, CDP-choline makes learning much easier. It also facilitates association and recollection of memorized information. Regular CDP-choline supplementation additionally increases the amount of ATP in neurons, which increases “mental energy”. 

In the brain, CDP-choline releases its two main components, choline and cytidine – another beneficial substance. Cytidine is mostly transformed into uridine, which takes part in the biosynthesis of the neuronal membranes. It also activates the nerve growth factor (NGF) that supports the generation of new neural cells, and that is crucial for efficient learning. Moreover, uridine increases the amount of available dopamine and its receptors, thereby noticeably enhancing motivation to work and the sense of satisfaction that comes from getting things done.

Occurrence: CDP-choline occurs naturally in the human organism, especially in the brain and intestines. However, it does not occur in food. Its concentration in the organism can be increased via supplementation.

Biochemistry: CDP-choline (citicoline; cytidine 5′-diphosphocholine) is an organic chemical compound from  the group of phospholipids. Upon oral administration its absorption reaches up to 95%. As it is readily water-soluble, its bioavailability is greatly improved. It is one of the three phospholipids that contain choline, the other two being Alpha-GPC and phosphatidylcholine. Similarly to Alpha-GPC, CDP-choline efficiently crosses the blood-brain barrier. Due to its choline component it is also a precursor of an excitatory neurotransmitter acetylcholine and an indirect compound in production of phosphatidylcholine – a phospholipid involved in the biosynthesis of cellular membranes. Citicoline contains cytidine, a precursor of uridine, a compound that additionally strengthens cellular membranes.

Fun fact: Citicoline is intended for regular supplementation, however, administered ad hoc is less effective relative to Alpha-GPC. This is due to the lower concentration of pure choline per molecule – i.e. 18.5% for CDP-choline and 40% for Alpha-GPC.

How does CDP-Choline | Citicoline work?

Improves memory: Acetylcholine is a neurotransmitter necessary for correct brain functioning. Its activity is required for quick information processing and smooth incorporation of new facts to the knowledge base. CDP-choline delivers the material to synthesize this important neurotransmitter. Thus, its supplementation increases the activity of acetylcholine and thereby enhances memorization and recalling of information – the processes that are crucial for effective learning.

Supports the nervous system: When molecules of CDP-choline enter the central nervous system, they are broken down to choline and cytidine. Choline is involved in the synthesis of acetylcholine, whereas cytidine is transformed into uridine. Uridine is needed for production of phosphatidylcholine – the main component of cellular membranes. Furthermore, it activates the so-called nerve growth factor (NGF), which promotes the development of axons and synapses – parts of neurons responsible for information transmission. In this way, CDP-choline enhances neuroplasticity, the ability to create new neural connections that are indispensable in acquiring and processing information.

Increases energy levels: Results of scientific studies have demonstrated that supplementation of CDP-choline over a few weeks increases the concentration of ATP in brain cells. ATP is a major cellular energy carrier and its increment promotes more efficient cellular processing. What is more, uridine obtained from transformed choline molecules has been proven to work as an antagonist of dopamine’s receptors and that is why its regular supplementation can increase the density of dopaminergic receptors. This way, dopamine’s influence on target cells is strengthened. The effects are not limited to an increased energy level and less procrastination, but also include intensified experience of joy.

Improves mood: Dopamine is a neurotransmitter that determines the energy level but is also responsible for motivation and correct functioning of the so-called “reward system”. The reward system is a brain network that enables happiness. CDP-choline, especially when administered regularly, increases the concentration of dopaminergic receptors and thereby significantly improves our mood and the sense of self-contentment.

CDP-Choline | Citicoline product specification


  • powdered raw ingredient
  • CDP-choline 99%; pharmaceutical quality
  • PET measuring tool 0.50 ml ~ 300 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

How to use CDP-Choline | Citicoline?


  • 300 – 600 mg
  • 1 – 2
  • without food
  • in the morning / during the day
  • 6 weeks of using – 2 weeks of break

How to stack CDP-Choline | Citicoline?

To improve memory:
To support the nervous system:
To increase energy level:
To improve general mood:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.