Sunifiram | Sunitropil™

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Sunifiram is a derivative of piracetam with interesting nootropic properties. It has a positive effect on the nervous system where it supports biochemical activity of the brain thus increasing cognitive efficiency and energy levels. Besides that, sunifiram effectively supports cognitive abilities and helps to maintain emotional stability.


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Sunifiram | Sunitropil™

Properties: Sunifiram is a completely new, synthetic compound developed in the early 2000s. It was created quite recently, which is why it drew attention to scientists. For this reason, many research centers are trying to establish how exactly it works. Numerous studies have proven that it has a strong nootropic effect – as it primarily affects the cognitive functions of the human brain. Thanks to supplementation with sunifiram, the absorption of new information becomes easier. Sunifiram stimulates the action of neurotransmitters – glutamate and acetylcholine – which supports the learning process and facilitates information processing.

However, learning would not make much sense if the acquired knowledge was to be quickly forgotten. That is why we also need a good memory. Memory, on the other hand, is largely dependent on acetylcholine. This neurotransmitter is responsible for the level of our concentration and the effectiveness of remembering. Due to the fact that sunifiram increases the activity of acetylcholine, it also improves the functioning of our memory. It also stimulates the brain structures responsible for long-term memory, which is why we remember new information for longer.

It has also been established that sunifiram has a beneficial effect on the metabolism of nervous cells. It improves this process, ensuring better intellectual performance. Moreover, it has been shown that this compound is able to improve mood, mainly because it stimulates the activity of glutamate. Sunifiram is therefore effective not only as a supplement that increases intellectual performance. It is also worth using it when we are in a bad mood and want to improve the functioning of the entire nervous system.

Occurrence: Sunifiram does not occur in nature. It is a compound obtained in the laboratory. The first synthesis of this compound was carried out in 2000.

Biochemistry: Sunifiram (DM-235) is an organic chemical compound that belongs to the group of ampakines – compounds that increase the activity of AMPA glutamatergic receptors. It is a derivative of piracetam, but is not included in the racetam group. Structurally it differs from racetams because the 2-pyrrolidone ring – characteristic for this group of compounds – in sunifiram remains open. This compound easily crosses the blood-brain barrier. In the body, it causes an increase in the activity of the main excitatory neurotransmitter – glutamic acid – by affecting the positive allosteric modulator of AMPA receptors. It also contributes to the increased activity of acetylcholine – a stimulating neurotransmitter.

Fun fact: Sunifiram, just like racetams, should be taken in combination with supplements that have a cholinergic effect, e.g. acetyl L-carnitine (ALCAR), CDP-choline or dimethylaminoethanol (DMAE).

How does Sunifiram | Sunitropil™ work?

Facilitates learning: Long-term potentiation (LTP) is a repetitive stimulation of a pair of neurons. Because of that the connection between them becomes stronger. This phenomenon is the basis for acquiring new information. The proper supply of neurotransmitters, such as glutamate and acetylcholine, is essential for LTP activation. Scientific research has shown that sunifiram increases their activity. In this way, it promotes the LTP and facilitates learning.

Improves memory: Acetylcholine is a very important neurotransmitter as it stimulates excitation of neurons. It not only participates in the induction of LTP, but it is also responsible for the speed at which the brain processes information and combines new data with information remembered previously. It is essential for the proper functioning of memory. Scientific studies show that sunifiram increases the production of acetylcholine. It also stimulates the activity of hippocampal neurons which are responsible for long-term memory. During clinical trials participants remembered the information acquired during the tests long after the end of supplementation period.

Increases energy level: Sunifiram is an agonist of AMPA glutamate-activated receptors. Its molecules bind to these receptors in order to mimic the action of a neurotransmitter. They have a similar effect on the activity of NMDA – other glutamate receptors. In addition, sunifiram stimulates the metabolism in the central nervous system, increasing the efficiency of neurons. As a result, taking this compound results in an increase in the level of “mental energy” and an improvement in intellectual performance.

Supports good mood: During clinical trials, a large proportion of volunteers taking sunifiram noticed an improvement of their mood. The mechanism of this action is not fully understood. Scientists speculate, however, that it may be related to the ability of sunifiram to normalize the glutamate metabolism, especially AMPA receptors. The influence of their activity on mood is currently the subject of intense research.

Sunifiram | Sunitropil™ product specification


  • powdered raw ingredient
  • sunifiram >99%; pharmaceutical quality
  • red micro-spoon ~5 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

How to use Sunifiram | Sunitropil™?


  • 5 – 10 mg
  • 1 – 2
  • without food
  • in the morning / during the day
  • 4 weeks of using – 2 weeks of break

How to stack Sunifiram | Sunitropil™?

To facilitate information acquisition:
To support memory:
To increase energy level:
To improve general mood:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.