Coluracetam | Colutropil™

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Coluracetam is a modern nootropic compound from the group of racetams. It is very well absorbable, crosses the blood-brain barrier easily and on top of that, its effects last extraordinarily long. These effects include a noticeable increase of focus and an enhancement of information acquisition. Clinical trials also demonstrated that coluracetam has a positive effect on mood.


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Coluracetam | Colutropil™

Properties: Coluracetam is a compound from the class or racetams – structurally similar compounds characterized by scientifically proven beneficial impact on cognitive performance. It is well absorbed from the gastrointestinal tract and it stays active for a very long time. Well, at least in comparison with other compounds. Coluracetam stimulates the activity of two important neurotransmitters: glutamate and acetylcholine. The optimal levels of both of them are crucial for efficient information acquisition. By stimulating their production, coluracetam makes learning much easier.

In order to remember newly acquired information the brain needs acetylcholine. Coluracetam increases the concentration of choline – a direct precursor of acetylcholine. Therefore, it improves the formation of memories as well as their recall. 

Where does the name “coluracetam” come from? First meaning is literal – it turns out that prolonged administration of this compound actually increases the acuity of perceived colors. Second meaning is more metaphorical: participants of clinical trials reported significant mood improvements paired with a noticeable drop in anxiety ratings. Hence, we might even conclude that coluracetam adds colors to both our inner world and the one outside.

Occurrence: Similarly to other racetams, coluracetam does not occur in nature. Instead, it is synthesized in laboratory conditions. The first synthesis took place in 2005, in a Japanese pharmaceutical company Mitsubishi Tanabe Pharma Corporation.

Biochemistry: Coluracetam (BCI-540) is an organic chemical compound classified as a racetam. Like all other racetams, its molecule contains a 2-pirolidon ring that is a derivative of γ-aminobutyric acid (GABA). Coluracetam is an equivalent of piracetam. It is absorbed from the gastrointestinal tract quickly. Just 30-60 minutes after administration it reaches maximum concentration in blood plasma. This compound easily crosses the blood-brain barrier. Most importantly, it increases the ratio of neuronal high affinity choline uptake (HACU), which is necessary for secretion of acetylcholine – an excitatory neurotransmitter. As a consequence, the concentration of acetylcholine in the central nervous system is upregulated. Colueracetam can also stimulate AMPA glutaminergic receptors and thereby increase the activity of the main excitatory neurotransmitter of the brain – glutamic acid. The combination of these two features leads to an increased level of serotonin, a neurotransmitter responsible for psychological well-being. Additionally, coluracetam has antidepressant and neuroprotective properties.

Fun fact: Coluracetam has an interesting effect on eyesight. When taken regularly, it can significantly increase the acuity of perceived color and the ability to see different colors.

How does Coluracetam | Colutropil™ work?

Improves learning: Long-term potentiation (LTP) is the fundamental principle of neuronal processing that enables the mind to learn. Basically, LTP occurs when a pair of neurons is repetitively stimulated and the connection between them becomes stronger. However, in order to produce the LTP effect the brain requires the appropriate level of resources such as glutamic acid and acetylcholine. It has been proven that coluracetam increases the activity of these neurotransmitters. Thereby, this compound promotes LTP effects in the brain which in turn makes learning easier. Moreover, the results of scientific studies showed that coluracetam’s effects last even up to 72 hours after administration.

Improves memory: Acetylcholine is a key neurotransmitter in the context of memory functions. It is often called “the accelerator” of the mind  because its optimal level is necessary for quick and efficient information acquisition and association. It is proven that coluracetam stimulates a process called high affinity choline uptake (HACU). Choline is a raw material needed for acetylcholine production. Intensification of HACU leads to an increase of cholinergic secretion and thereby supports the ability to remember and recall information.

Supports a good mood: The results of clinical trials show that coluracetam benefits the mood, especially in critical situations. This effect comes from the ability of racetams to influence the activity of acetylcholine and glutamic acid. These neurotransmitters are essential for optimal cognitive functioning but their proper levels are also crucial for psychological well-being.

Improves stress resilience: Scientific research demonstrates that regular supplementation of coluracetam helps to decrease anxiety level. Researchers believe that this effect is a result of racetam’s influence on activity of glutamate. As it turns out, overactivity of this neurotransmitter can be toxic for neurons and increase the level of anxiety. It has been proven that coluracetam helps to decrease toxicity of glutamate.

Coluracetam | Colutropil™ product specification


  • powdered raw ingredient
  • coluracetam >99%; pharmaceutical quality
  • blue micro-spoon ~5 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

How to use Coluracetam | Colutropil™?


  • 10 – 20 mg
  • 1 – 2
  • without food
  • in the morning / during the day
  • 6 weeks of using – 2 weeks of break

How to stack Coluracetam | Colutropil™?

To facilitate learning:
To improve memory:
To improve general mood:
To improve stress resilience:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.