Picamilon | GABA-Nicotinol™

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Picamilon is a highly absorbable compound with nootropic properties. It is obtained by combining the molecules of GABA neurotransmitter and vitamin B3. As it is able to regulate the level of GABA in the organism, it helps to reduce anxiety, increase self confidence and improve cognitive performance. Picamilon is also a good option for those who struggle with sleeping issues due to chronic stress.

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Picamilon | GABA-Nicotinol™

Properties: Picamilon is synthesized from two natural compounds: an inhibitory neurotransmitter GABA and vitamin B3 (niacin). Thanks to this structure, picamilon’s absorption rate is as high as 80% while it is able to cross the blood-brain barrier easily. In the central nervous system this compound is transformed back to its main components – both beneficial for the brain. Thus, its functioning is precisely directed and therefore its effects are observable shortly after administration.

Since its discovery, dated over 50 years ago, picamilon’s many properties have been intensely investigated. Clinical trials showed a significant improvement of participants’ mood combined with a major decrease of anxiety. Moreover, the group that supplemented picamilon also displayed higher self confidence and increased focus than the placebo group. This effect was related not only to regulation of GABA secretion but also to improved oxygenation of the brain and higher activity of the so-called “reward system”. Therefore, supplementation with picamilon is a perfect solution for those whose stress level is so high that it impedes their effectiveness. Furthermore, its effects will definitely be appreciated before any stressful public speech. 

At the end of the day, picamilon can help you to relax and prepare for the nocturnal rest. Its supplementation can make the sleep healthier and more effective. Thus, if you deal with a large amount of stress but you need to stay focused and calm even in challenging situations, you will be well advised to make yourself familiar with the fascinating properties of this compound.

Occurrence: Picamilon does not occur in nature. Instead, it is synthesised in laboratories. It was discovered for the first time during research conducted by a team of Russian scientists:  V. M. Kopelevich, L. M. Shmuylovich and V. I. Trubnikov in the All-Union Research Institute of Vitamins (Moscow, Russia; previously USSR). The first synthesis was completed in the year 1970. 

Biochemistry: Picamilon (nicotinic-gamma-aminobutyric acid) is an organic chemical compound synthesized by combination of GABA neurotransmitter (gamma-aminobutyric acid) and B3 vitamin (niacin). Its absorption rates are between 50% and 80%. This compound is soluble in water, its absorption from the gastro-intestinal tract is quick and easy, and it remains in the organism for a long time. It is not metabolized and therefore it is excreted from the organism with urine. Unlike pure GABA, picamilon can cross the blood-brain barrier easily thanks to niacin. In the central nervous system it becomes hydrolyzed and decomposed to its two components. Although both can influence the functioning of the brain, their separate supplementation does not provide the same effects as picamilon administration.

Fun fact: The supplementation of picamilon is less popular in the West than in the East, where it has been used since the early ‘70s. The reason for that is probably related to the history of its synthesis. It was developed in the USSR in the late 1960s, during the Cold War. Afterwards its bioactivity was under intense investigation. Most of the studies were written in Russian and published exclusively in Russian scientific journals. Additionally, they were not indexed in international databases, which limited the scope of their audience.

How does Picamilon | GABA-Nicotinol™ work?

Supports stress resilience: GABA increases the excitability threshold of neurons. Thereby, it calms down the entire central nervous system and in turn – the whole organism. As a result, fear and anxiety levels drop tremendously. Some scientific studies report a significant improvement of psychological well-being and mood in those participants who supplemented picamilon. This improvement was an effect of the increase in endorphins (“happiness hormones”). On top of that, picamilon stimulates the activity of the so-called “reward system” of the brain. In this way, the sense of contentment and the satisfaction from our own achievements also increase.

Helps with self-confidence: When a molecule of picamilon reaches the brain, it decomposes into niacin (B3 vitamin) and GABA. The results of scientific studies demonstrated that niacin activates the neurons belonging to the nucleus accumbens. This structure is a part of the brain’s “reward system”. The activity of this system induces the state of happiness while reducing fear and anxiety. During clinical trials the participants who received picamilon were more open and had a success-oriented attitude more often than those who received placebo. Therefore, the supplementation of picamilon can increase self-confidence.

Improves cognitive performance: The research evidence suggests that picamilon benefits the health of the central nervous system and in turn – the efficiency of the mind. It’s possible because this compound increases the blood flow in the blood vessels of the brain, thereby supplying neurons with more oxygen and nutrients. This effect combined with the influence of picamilon on the secretion of neurotransmitters can improve cognitive performance. The results of clinical trials demonstrated that the participants treated with picamilon performed better in both memory and attention tests than those who were given placebo.

Stimulates regeneration of the organism: GABA is responsible for many key processes, including the ability to calm down. Therefore, the optimal activity of this neurotransmitter is crucial in order to prepare the organism for its nocturnal rest. Additionally, GABA promotes the NREM sleep phase that is related to physiological regeneration of the body. A strong or chronic stressor sometimes suppresses the activity of GABA, which may cause trouble with falling asleep and achieving relaxation. Picamilon normalizes the activity of this important neurotransmitter. Therefore, picamilon’s supplementation helps to wind down after a challenging day, improves the sleep quality, and stimulates the natural restorative processes.

Picamilon | GABA-Nicotinol™ product specification

 

TYPE OF PRODUCT:
  • powdered raw ingredient
STANDARDIZATION:
  • picamilon >99%; pharmaceutical quality
MEASURING:
  • steel measuring tool 0.30 ml ~ 100 mg
PACKAGING:
  • airtight ALU-PET bag
INTENDED USE:
  • nutrition, neuroregulation, herbal medicine
LEGAL STATUS:
  • ingredient admitted to trading in the EU and the US

How to use Picamilon | GABA-Nicotinol™?

 

RECOMMENDED SERVING:
  • 50 – 200 mg
SERVINGS PER DAY:
  • 1 – 2
BEST ABSORPTION:
  • without food
WHEN TO USE:
  • during the day / before bedtime
OPTIMAL CYCLE DURATION:
  • 3 – 4 days a week

How to stack Picamilon | GABA-Nicotinol™?

To improve stress resilience:
To improve self-confidence:
To improve cognitive abilities:
To support natural regeneration:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.