Melatonin | PharmaMelatonin™

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Melatonin is a compound naturally produced in the pineal gland. It is crucial for maintaining proper circadian rhythm. As a supplement melatonin helps to reduce the effects of insomnia – it makes falling asleep easier and intensifies regeneration during sleep. It is also excellent when it comes to reducing symptoms of jet-lag. Moreover, it has a beneficial influence on the entire nervous system.

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Melatonin | PharmaMelatonin™

Properties: We all know that good sleep is crucial for proper functioning of any organism. Nevertheless, our sleep duration keeps getting shorter. Over the past century, the time of night rest has decreased by an hour (on average) every 20 years. Modern, fast-paced world overloaded with information often leaves us sleepless. Scientists indicate that more and more people have some kind of difficulty with sleeping. How can we deal with that?

The circadian rhythm is regulated by melatonin. The production of this neurohormone occurs in the brain and is stimulated by darkness. These days, ever present light and illumination coming from smartphone screens successfully downregulate the secretion of melatonin and thereby shorten our sleep duration. Thus, delivering to the organism an extra portion of this neurohormone allows us to maximally exploit the time left for regeneration. Sleep deprivation not only lowers our performance at work, but also adversely affects the ability to focus, which can increase the likelihood of a road accident for example. 

Lack of sleep has a negative influence on our mood, too. It makes us irritable and forgetful. This, in turn, can lead to stressful situations, which will make falling asleep even more complicated. And so we fall into a downward spiral. Scientific studies prove that melatonin supplementation improves the mood and helps to deal with daily stressors. Melatonin can also protect the organism against other types of stress. It is a strong antioxidant, and thus it can prevent the phenomenon of oxidative stress. Moreover, it limits the formation of harmful protein deposits in the brain. Therefore, it helps to maintain mental fitness longer. Lastly, it has been demonstrated that melatonin stimulates the metabolism, which tends to get slower as we age. Maybe that’s why high activity of melatonin was observed in people who lived over 100 years? Or maybe they could live for so long thanks to melatonin?

Occurrence: Melatonin occurs naturally in animals, plants, and microorganisms. In the human body it is secreted mostly in the pineal gland, a small organ found in the center of the human brain. Its tiny amounts are also produced in the retina, digestive tract, bone marrow and platelets. It is also present in plant-based food. Melatonin can be found in cereals: oats, wheat, barley and rice, as well as e.g. tomatoes, corn and grapes. However, its amount is highly variable and depends on the plant’s type, cultivation method, soil conditions and degree of development. Melatonin can be found in herbs: Chinese lemon (Schisandra chinensis), Chinese angelica (Angelica sinensis) and red sage (Salvia miltiorrhiza).

Biochemistry: Melatonin (N-acetyl-5-methoxytryptamine; MEL) is an organic chemical compound classified as a biogenic amine (derivative of serotonin). It is well soluble both in water and lipids. Thus, it easily crosses biological barriers of the organism. Bioavailability of MEL in the organism is usually around 15%. After oral administration it is metabolized in the liver and, partially, in the kidneys. It is a hormone derivative of tryptophan (Trp), and therefore serotonin. Melatonin is also a strong antioxidant. It has the ability to neutralize free radicals and supports the functioning of antioxidative enzymes. Thereby, it protects proteins, lipids, and nucleic acids.

Fun fact: The main role of melatonin in the human body is the regulation of circadian rhythm: the cycle of wakefulness and sleep. Similarly, in plants melatonin regulates leaf and flower movements at night, as well as plant growth and seed germination.

How does Melatonin | PharmaMelatonin™ work?

Improves sleep quality: Already in the 1980s it has been discovered that increased melatonin secretion in the evening is related to the feeling of drowsiness. Thus, it signals the organism that it is time for rest. Research evidence suggests that melatonin supplementation leads to significant improvement of sleep quality. This neurohormone not only makes falling asleep easier but also prolongs the REM sleep phase, which is crucial for optimal regeneration of the nervous system. Its administration is especially recommended to elderly or those whose natural production of melatonin is lower. It is also handy in cases such as jet-lag syndrome, in which switching time zones leads to problems with circadian rhythm.

Supports good mood: Low mood caused by chronic stress is often accompanied by sleep disturbances. At the root of this phenomenon are abnormalities in melatonin secretion. Studies carried out with an animal model proved that melatonin supplementation contributes to the improvement of mood and counteracts the effects of chronic stress. The results of research on the use of melatonin in the so-called seasonal depression are promising as well. As it turned out, supplementing this neurohormone significantly improved the psychological well-being of the volunteers who participated in the study.

Improves general vitality: There are scientific studies measured the activity of the pineal gland in those elderly who lived above 100 years. Results demonstrated that it was comparable to the level recorded in the much younger population. What’s more, melatonin prevents the aging-related impairment of mitochondria function, where energy required for metabolic processes is produced. Thanks to its antioxidant properties, it also protects important cell structures, such as DNA, against the effects of free radicals. Due to these factors, melatonin supplementation improves the health and overall condition of the body.

Protects the nervous system: Scientific evidence confirmed that melatonin supplementation significantly improves the functioning of the central nervous system in people who suffer from deterioration of cognitive abilities such as memory and concentration. Moreover, it is proven that it can help to regulate the sleep-wake cycle. It can also reduce the death of neurons caused by accumulation of toxic compounds such as beta-amyloid. Apart from that, melatonin is a powerful antioxidant, so it protects the cells of the brain against the harmful effects of free radicals. Its use as an adjunct to migraine therapy is also being investigated.

Melatonin | PharmaMelatonin™ product specification

 

TYPE OF PRODUCT:
  • powdered raw ingredient
STANDARDIZATION:
  • melatonin >99%; pharmaceutical quality
MEASURING:
  • yellow micro-spoon ~1.5 mg
PACKAGING:
  • airtight ALU-PET bag
INTENDED USE:
  • nutrition, neuroregulation, herbal medicine
LEGAL STATUS:
  • ingredient admitted to trading in the EU and the US

How to use Melatonin | PharmaMelatonin™?

 

RECOMMENDED SERVING:
  • 1 – 5 mg
SERVINGS PER DAY:
  • 1
BEST ABSORPTION:
  • without food
WHEN TO USE:
  • before bedtime
OPTIMAL CYCLE DURATION:
  • 4 weeks of using – 2 weeks of break

How to stack Melatonin | PharmaMelatonin™?

To improve sleep quality:
To improve general mood:
To support vitality:
To improve memory and attention:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.