Improves stress resilience: The reaction of the body to stressful stimuli is regulated mostly by the hypothalamic-pituitary-adrenal (HPA) axis. Hypothalamus can be considered a mediator between the nervous system and the endocrine system. Based on the signals that come from the brain, it is able to activate the flow of specific hormones. One of them is corticoliberin that stimulates the pituitary gland to secrete corticotropin. This last hormone takes part in the production and release of cortisol – the so-called “stress hormone” – whose excessive level over a long time can lead to many negative effects usually associated with chronic stress. The HPA axis activity is regulated by many neurotransmitters but the most important one in that regard is GABA that has a strong influence on the intensity of stress resilience and helps to stabilize emotions. Research indicates that the ingredients of our formula effectively regulate GABA activity but also affect the release of cortisol. Gotu Kola is able to increase the activity of an enzyme involved in production of this neurotransmitter up to 40%! And Brahmi improves density of GABA receptors in the synapses. All these effects inhibit the HPA axis and thus reduce the intensity of stress reactions. Lion’s Mane and Ginkgo biloba do not affect the activity of GABA directly. However, scientists suggest that Lion’s Mane might have some influence on the hippocampus that is the most active when processing memories and emotional reactions. Ginkgo, on the other hand, reduces cortisol release during stressful events and helps to control blood pressure. Therefore, a combination of those 4 ingredients will help to stay strong in the face of challenges that are typical for the modern world.

Improves the condition of the nervous system: It is a common knowledge that chronic stress has a bad influence on the nervous system – it might impede clarity of thought and disturb intellectual capacity. The ingredients found in our formula counteract those unfavorable effects. They increase the activity of acetylcholine – a neurotransmitter that is crucial for efficiency of cognitive functions, particularly memory, attention and the ability to connect the facts. Lion’s Mane stimulates the production of acetylcholine while Brahmi and Gotu Kola inhibit the breakdown of this neurotransmitter. On the other hand, Ginkgo biloba increases its density within the prefrontal cortex – a brain region that is particularly active during intellectual operations. Ginkgo also modulates the activity of glutamate – the neurotransmitter that plays an important role in long-term potentiation (LTP) that is a basic process governing information acquisition. Besides that, this herb improves blood flow within the arteries that supply oxygen and nutrients necessary for the efficient work of the brain. The ingredients of our formula support the development and regeneration of the brain, particularly by affecting the activity of NGF and BDNF – the proteins that stimulate the process of neurogenesis (formation of new nerve cells) and neuroplasticity (creating connection between neurons). The neuroprotective properties of those herbs are also very important. Lion’s Mane reduces the accumulation of beta-amyloid that might be harmful for the neurons that produce acetylcholine. Brahmi, on the other hand, has the ability to chelate heavy metals, facilitating their removal. It has also been proven that it might slow down the changes that occur due to the aging process. Working in synergy, both Brahmi and Ginkgo biloba neutralize free oxygen radicals and protect delicate cellular structures from damage. All those properties make this combination of natural ingredients an excellent support for a fatigued brain.

Supports a good mood: There are two neurotransmitters that can instantly be associated with a positive attitude: dopamine and serotonin. The first one is responsible for the activity of the reward system that is related to the feelings of pleasure and motivation. The second one is commonly known as a “happiness hormone” as it usually induces mental comfort and a sense of joy. The ingredients of our formula support the activity of those two neurotransmitters. Brahmi upregulates tryptophan hydroxylase – an enzyme that catalyzes the first stage of serotonin production. It has been proven that this herb might increase the level of this neurotransmitter particularly in the hippocampus – a brain region that is involved in the processing of memory and emotions. Ginkgo biloba sensitizes serotonin receptors, hence this compound can affect the neurons more efficiently. Besides that, Ginkgo helps to increase dopamine level in the prefrontal cortex that is important in terms of emotional reactions. Gotu Kola and Lion’s Mane are also able to regulate the density of dopamine and serotonin. The scientists believe that Lion’s Mane may act as a mild inhibitor of MAO – the enzyme that breaks down the molecules of those neurotransmitters. That would mean that this herb can improve their ability to affect specific receptors. Anyway, each ingredient has a positive effect on BDNF and NGF – the compounds that stimulate neurogenesis and neuroplasticity. It has been proven that during chronic stress and/or lowered mood their production is disrupted. Thus, the stimulation of those endogenous neurotrophic factors is of great importance for mental health. The results of clinical tests indicate that all the herbs that can be found in our formula support psychological well-being and can possibly improve perceived quality of life.