COMFORTIL™ Original

Improves stress resilience: The reaction to a stressful stimulus includes the activation of an interactive system called the hypothalamic-pituitary-adrenal (HPA) axis. It gives signals for the central nervous system to release a mix of hormones and changes the whole body to a different mode so it can deal with difficulties. The longer the stressful event lasts, the longer this “emergency mode” is active. It is usually related to the increase of cortisol – a hormone that is important in terms of a proper reaction to stress but can also cause some unpleasant or even harmful effects, especially when its level is elevated for a longer time. The HPA axis can be regulated by many neurotransmitters but one of them is especially important as it can inhibit this system. It is gamma-aminobutyric acid (GABA) that, in general terms, helps to calm down in difficult situations. All ingredients that can be found in our formula support the activity of GABA in every aspect of neuronal activity. Brahmi and Lemon balm increase the level of a GAD enzyme that acts as a catalyst in the production of GABA. L-theanine also stimulates the activity of this neurotransmitter (even by up to 20%), however, the exact mechanism of this effect is still unclear. Magnolia increases the density of GABA receptors. Additionally, the active substances contained in this herb act as positive allosteric modulators of benzodiazepine receptors. Those types of receptors are actually a part of GABA-A receptors. Their activation (induced by magnolia) stimulates GABA activity. Thanks to that, the molecules of this neurotransmitter can affect their target neurons. Lemon balm inhibits the enzyme that breaks down GABA so this neurotransmitter can remain in the synapses and affect the cells for a longer time. All in all, the herbs that are included in our recipe make GABA production more efficient, induce stronger effects of this neurotransmitter and slow down the breakdown of its molecule. Thanks to that, the brain – but in a big picture the whole body – can be more stress resilient and stay calm.

Improves mental well-being: GABA is one of the key compounds involved in stress resilience. But there are also other neurotransmitters necessary for psychological comfort. Serotonin is commonly known as a “happiness hormone” for a specific reason – it simply induces a sense of joy and supports a good mood. Dopamine, on the other hand, is released during the activation of the reward system and is related to pleasure, satisfaction and motivation. The ingredients found in our natural formula can influence those parts of neuronal activity. Brahmi increases the expression of genes that code tryptophan hydroxylase – an enzyme that takes part in serotonin production. The active compounds of magnolia bind to the receptors of serotonin and dopamine. Scientists suggest that this is the mechanism through which they can regulate the activity of those neurotransmitters. Brahmi also has a regulatory function. It has been proven that it helps to maintain the amount of serotonin and dopamine at a proper level, preventing sudden changes caused by stress. L-theanine improves the activity of GABA but it is not the sole property of this compound. It can also promote brain waves (cycles of bioelectrical brain activity) with the alpha frequency. Their presence usually indicates that the brain is relaxed but stays focused and aware. All these effects make our formula a solid and long-lasting support for mental comfort.

Supports the brain: Stress usually has a negative impact on one’s mood but there might be even more issues. Under stress some people experience attention problems and less clarity of mind. Generally, the spheres of the nervous system that are responsible for cognitive functions might be disrupted. All the ingredients contained in our formula will provide support in that regard as they are able to improve stress resilience by stimulating the activity of GABA. But their influence on cognitive activity is much broader. Acetylcholine is particularly important here as this substance acts as a neurotransmitter that determines the efficiency of data processing within the brain and facilitates consolidation of memory. Brahmi stimulates the activity of choline acetyltransferase – an enzyme that is a catalyst in the production of acetylcholine. Magnolia stimulates the release of this neurotransmitter to the synapses and facilitates binding its molecules to the receptors. Brahmi, Magnolia and Lemon balm are acetylcholinesterase inhibitors which basically means that they reduce the activity of an enzyme that breaks down acetylcholine molecules. So, when this neurotransmitter is produced in greater amounts, gets quickly released to the synapses and breaks down at a slower rate, it can affect the cells more effectively – providing positive effects on memory and attention. But going back to stress, it is worth pointing out that nervous tension can even physically damage the nerve cells. L-theanine, Lemon balm and Brahmi might counteract this effect because they stimulate neurotrophic factors that are necessary for neurogenesis – the production of new neurons. They are also crucial for the cells to create new connections which is particularly important for memory and learning abilities. Additionally, L-theanine will help to get into a proper mood. This natural compound from green tea stimulates alpha brain waves (8-13 Hz). They are typical for the mental state known as “relaxed awareness” that is great for learning. Those stress-mitigating properties will certainly reduce the negative impact of stress and help to process information more efficiently.