Meldonium is a synthetic compound that provides great support for active people. It affects the metabolism of L-carnitine, supporting the production of ATP – the main energy carrier – during intense exercise. In addition, it helps to expand blood vessels, allowing more oxygen to reach the cells. Meldonium has a beneficial influence on physical performance as well as cognitive functions.

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Meldonium | MeldoPure™

Properties: Meldonium is an interesting, nootropic compound that has been synthesized in a laboratory thanks to a Lithuanian chemist Ivars Kalvinš in the 1970s. In the Western Europe, it is still not very popular, however, in the Eastern parts of this continent it is more common. Meldonium is often used among sportspeople – including athletes or simply those who enjoy regular activity – in order to improve their performance. And we should probably point out that it can be really effective in that regard.

This compound influences the activity of L-carnitine, which in turn plays an important role in lipid metabolism. L-carnitine transports long-chain fatty acids to the mitochondria, where the acids are then oxidized. Due to this mechanism energy necessary for the cells to function properly can be released. Under “normal conditions”, i.e. with the right amount of oxygen, L-carnitine stimulates fatty acid oxidation, providing about 80% of ATP production. However, when the amount of oxygen is limited, e.g. during intense exercise, a more efficient mechanism for obtaining ATP is the breakdown of glucose, since much less oxygen is consumed during this process.

Meldonium suppresses the effects of L-carnitine and reduces the transport of fatty acids in the mitochondria. As a result, the body can switch to an alternative metabolic pathway, particularly carbohydrate oxidation. This way of acquiring energy is most beneficial for resistance training that is intense but not too long. Researchers also suggest that meldonium may contribute to reducing the time required for recovery between workouts. In addition, this synthetic compound relaxes the smooth muscles of blood vessels, thus promoting blood flow and oxygen transport to cells. As a result, it improves physical performance and helps to lower blood pressure, while also benefiting cognitive functions such as memory or learning abilities, as a properly oxygenated brain can operate at full capacity. 

The potential of meldonium in alleviating the symptoms of hangover has caught attention of researchers. Interestingly, this compound is being tested as a support for those struggling with addiction. Results of studies published so far indicate that meldonium can promote efficient liver functioning, reduce the time it takes to get back on your feet after a heavy party, and even alleviate symptoms of withdrawal.

Occurrence: Meldonium does not occur naturally in nature. It is obtained by chemical synthesis in professional laboratories. It was first produced in the late 1970s at the Institute of Organic Synthesis of the Latvian Academy of Sciences.

Biochemistry: Emoxypine is a derivative of pyridoxine (vitamin B6). Its full chemical name is 2-ethyl-6-methyl-3-hydroxypyridine.

Fun fact: Meldonium is so effective in promoting physical performance that in January 2016 the World Anti-Doping Agency (WADA) listed this compound as a prohibited substance. This action resulted in a number of disqualifications. One of the first to be affected was Russian tennis player Maria Sharapova, a silver medalist at the 2012 London Olympics, winner of numerous tournaments and WTA Tour ranking leader.

How does Meldonium | MeldoPure™ work?

Supports physical endurance: Meldonium is often used by athletes and those who wish to improve their performance. In 2015, even before it was placed on the list of banned substances by WADA, results of tests for its presence were positive in many sportspeople, especially those that require high muscle strength. Although few research papers on this matter are available, they prove that this substance significantly improves exercise tolerance. Perhaps it’s because meldonium can restore the balance between the availability of oxygen in cells and the demand for it. There is also evidence that it reduces the time needed for the body to recover from intense exercise.

Regulates metabolism: The production of ATP (energy carriers) in the mitochondria can take place in two ways. The first involves the oxidation of fatty acids and requires relatively large amounts of oxygen. The second, more “cost-effective”, is the breakdown of glucose. Meldonium inhibits the transport of fatty acids into the interior of mitochondria, thus kind of switching these organelles to the second way. It makes it possible for the mitochondria to produce more ATP with the same supply of oxygen during intense mental and physical effort. This effect allows the body to work more efficiently and helps to perform better during workouts.

Supports the nervous system: Studies suggest that meldonium can benefit not only the muscles, but also the central nervous system. During clinical trials, this compound has been proven to support cerebral hemodynamics in patients after a stroke or ischemia. Other studies have shown that meldonium promotes blood circulation in the vessels supplying the brain, and improves cognitive functions, including memory and the ability to focus. It also alleviates the negative effects of stress on intellectual performance.

Improves overall vitality: Many of the beneficial effects of meldonium are based on the ability to support cardiovascular function. Switching the metabolism from fatty acid oxidation to glucose breakdown – similar to what happens in skeletal muscles – allows oxygen to be managed with better efficiency. This is actually favorable for the heart in case of hypoxia. Therefore, this substance will work well as a support for the treatment of ischemic disorders. Besides the cardioprotective effect, it can dilate blood vessels and normalize blood pressure. Research results also show that meldonium helps to lower blood glucose levels, which is important in diabetes or metabolic syndrome. In addition to that, it can facilitate recovery from alcohol addiction, as it alleviates the symptoms of withdrawal syndrome. All this makes meldonium a valuable support for the entire body.

Meldonium | MeldoPure™ product specification

 

TYPE OF PRODUCT:
  • powdered amino acid
STANDARDIZATION:
  • pure meldonium dihydrate (>99%, pharmaceutical grade)
MEASURING:
  • 1 ml PET measuring tool containing 600 – 800 mg of meldonium (depending on the batch)
PACKAGING:
  • airtight ALU-PET foil bag with a desiccant packet
INTENDED USE:
  • nutrition, neuroregulation, natural medicine
LEGAL STATUS:
  • ingredient admitted to trading in the EU and the US

How to use Meldonium | MeldoPure™?

 

RECOMMENDED SERVING:
  • 500 – 1000 mg
SERVINGS PER DAY:
  • 1 – 2
BEST ABSORPTION:
  • without food
WHEN TO USE:
  • during the day / before workout
OPTIMAL CYCLE DURATION:
  • 6 weeks of using – 2 weeks of break

How to stack Meldonium | MeldoPure™?

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.