Improves sleeping quality: Insomnia can have many causes, but they all come down to one thing: inadequate activity of neurotransmitters responsible for inhibiting the nervous system, which affects the whole body. SLEEP-BOX™ Herbal Synergy can help to improve that balance. Its ingredients support those areas of neuroactivity that are key to falling asleep and sleeping without issues. One of them is controlled by adenosine. The levels of this compound tend to be lower in the morning and then rise during the day to reach a maximum in the evening, so it can induce drowsiness. Melatonin has a similar effect – its secretion intensifies after dusk and is a signal for the body to fall asleep. But this feeling of drowsiness alone wouldn’t be enough – after all, it is nearly impossible to rest feeling anxious or mentally agitated. Therefore, it is necessary to ensure proper activity of GABA – the main inhibitory neurotransmitter. It blocks unnecessary and redundant nerve impulses, preventing overstimulation of the brain, which ultimately helps to calm down the body as well. The ingredients of this formula improve the activity of adenosine (often disrupted by caffeine), stimulate production of melatonin (reduced due to artificial light sources, e.g. screens of electronic devices) and enhance the effects of GABA (which can be lowered because of chronic stress). Consequently, they help to relax the body and calm the nerves down, which makes the sleep more efficient. They do not disturb the natural rhythm of sleep phases REM and NREM. It is particularly important because both of them have different functions. During the REM phase, memory consolidation occurs while NREM promotes secretion of growth hormone, stimulating recovery processes. Our formula will help to rest even after the most demanding day and help to get up refreshed, ready for new challenges.

Improves stress resilience: One of the most common causes of sleep problems is a long-term exposure to stress. In terms of proper neural activity, that situation can disrupt the effects of GABA in particular. This brain chemical controls bodily responses to stress. It influences the hypothalamic-pituitary-adrenal (HPA) axis – a functional system that gets triggered in stressful situations. Stimulation of the HPA axis results in the secretion of large amounts of cortisol, which is responsible for many of the negative effects induced by stress. The ingredients of SLEEP-BOX™ Herbal Synergy support GABA activity. They intensify the production of the GABA-A receptor subunit. They help to exert better effects on specific cells after the molecules of this brain chemical attach to receptors. These ingredients can interact with GABA receptors similarly to their natural ligand. In addition, they inhibit enzymatic breakdown of GABA molecules and their removal from synapses. In effect, this compound can influence the nervous system for a longer time and with more pronounced results. The measurable changes that these herbal extracts provide are the reduction of blood pressure, heart rate or cortisol levels. This shows that the body calms down. Hence, our preparations improve stress resilience and alleviate the unpleasant impact of stress on the body.

Supports well-being: It is very hard to enjoy a peace of mind when we don’t get a proper amount of rest. On the other hand, we may have real trouble sleeping when our mind is racing or uneasy. That is why we designed our formula so it can affect these aspects of our lives as well. The ingredients of SLEEP-BOX™ Herbal Synergy include the direct precursor of serotonin, that quickly reaches the nervous system, where it is transformed into a fully functional neurotransmitter. Other herbal extracts found in these preparations ensure that serotonin molecules remain in the synapses for a longer time, so they can interact with specific receptors. They are able to inhibit the activity of proteins that transport this substance back to the cell. Besides that, they reduce the activity of enzymes that break down dopamine and serotonin, which is particularly important because both these compounds have key roles in the organism. The first one is released during the stimulation of the reward system in the brain, thus it is responsible for motivation and satisfaction. Serotonin, on the other hand, helps to experience mental well-being. Moreover, the ingredients of this formula enhance the activity of GABA, which essentially relaxes the body, calms down the brain and facilitates emotional stability. All these effects make our extracts a great choice for psychological wellness.

Supports the nervous system: If we don’t get enough sleep, we may experience fatigue – not only physically but also in terms of mental well-being. That’s because a proper amount of sleep is essential for the brain to regenerate. Our formula can come in handy in this field as well because its ingredients support the development and recovery of the central nervous system. They stimulate the secretion of neurotrophins – molecules capable of intensifying neurogenesis and neuroplasticity, i.e. the processes that lead to formation of new nerve cells and connections between them. These mechanisms are crucial for efficient functioning of the nervous system and support cognitive abilities. Herbal extracts of this formula help to counteract free radicals that in excessive amounts can be toxic to neurons and potentially damage their structures. These ingredients also lower the risk of forming beta-amyloid deposits, the accumulation of which is one of the main factors that promote development of Alzheimer’s disease. And since they have a positive effect on the natural rhythm of sleeping, they help to consolidate memory, so it might be stored for a longer time. What is more, SLEEP-BOX™ Herbal Synergy stimulates the production and inhibits the breakdown of acetylcholine – a neurotransmitter that is actually crucial for concentration, quick and clear thinking as well as effective information acquisition. All in all, this natural formula is a great choice for an overwhelmed mind that needs to recover.