SLEEP-BOX™ Herbal Synergy is an excellent combination of high quality herbal extracts that will help you to fall asleep and effectively improve the quality of sleeping. This special formula reduces stress symptoms and stabilizes mood, facilitating relaxation. It also has a positive influence on the nervous system as it can protect neurons from harmful factors and supports regeneration.

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SLEEP-BOX™ Herbal Synergy formula properties

Our human organism needs an adequate amount of sleep in order to function properly. After all, it is one of the most important biological needs of the body. During a night’s rest, many crucial processes occur, such as memory consolidation and brain tissue recovery. But sleep is also very important to stabilize basic mechanisms and various functional systems. Proper amount of sleep helps to regulate blood pressure, strengthens the immune system, promotes scavenging of free radicals, and even reduces the risk of mood disorders as well as neurological ailments. That’s why it is so important to ensure that our body gets the right amount of sleep, and, above all, that the quality of rest is good enough. We developed SLEEP-BOX™ Herbal Synergy specifically for people who need support in that regard. Our natural formulas are based on the synergistic activity of herbs that have been used for centuries in herbal medicine and show great efficacy. Thanks to modern scientific research, we can pinpoint particular mechanisms of action that components of our recipe induce.

Studies indicate that extracts of this formula stimulate the activity of GABA – the main inhibitory neurotransmitter that limits nerve impulses that are in excess. It is crucial not only for the body to prepare for sleep, but also significantly relieves symptoms of stress. The ingredients of SLEEP-BOX™ Herbal Synergy have been found to stimulate GABA receptors similarly to their natural ligand, and inhibit the deactivation of this neurotransmitter, making it easier to achieve a state of relaxation and peace of mind without which it would be difficult to fall asleep effectively. Besides that, it is worth mentioning that these ingredients enhance the activity of serotonin that acts as a precursor for melatonin, which is known as a sleep hormone for a reason. In fact, melatonin is one of the brain chemicals that regulate our circadian rhythm, because it makes us sleepy in the evening. During sleep, however, it is gradually removed from the brain to start accumulating back in the nerve tissue during the day. Thanks to this cycle, we can feel fresh and rested in the morning, while after sunset we feel the need to give our body a little bit of rest. By the way, adenosine shows a similar effect as it is able to inhibit the nervous system, especially in the evening, when we are exposed to less light. The results of scientific research suggest that herbs contained in this formula increase the activity of adenosine as well as melatonin, thus making it easier to fall asleep and stabilizing the work of our natural, internal clock.

In addition to that, let’s point out that these ingredients have a beneficial effect on the condition and functioning of the central nervous system. They have a neuroprotective effect – they contribute to reducing levels of beta-amyloid, excess of which is one of the risk factors for Alzheimer’s disease. At the same time, they help to neutralize free radicals that can be harmful to sensitive structures of neurons. What is more, the extracts found in our formula enhance the activity of acetylcholine, which acts as a neurotransmitter able to support cognitive functions as well as efficient transmission of signals between neurons. They also intensify the process of neurogenesis that enables the production of new nerve cells, and support neuroplasticity – the ability to create new connections between cells, which is a basic mechanism of learning. Let’s remember that this formula interacts with neurotransmitters that are particularly important in terms of well-being, including dopamine and serotonin. That way, it can improve cognitive functioning, but also provide a good mood and better stress resilience, which can be measured by a reduction in the level of cortisol, the so-called “stress hormone”.

SLEEP-BOX™ Herbal Synergy is a special formula based on 3 synergistic preparations that comprehensively help to fall asleep and improve sleeping quality. We recommend it especially as a natural way to calm down and relax. The formula can also help to maintain a positive attitude and relieve nervous tension. To maximize the effects, it should be used in the evening, when we’re preparing for a good night’s rest.

Ingredients of 5-HTP BioSynergy™:

5-HTP | Griffonia simplicifolia
  • extract 99% 5-HTP (200 mg / 2 caps.)
5-HTP is an amino acid that occurs in nature. It is extracted from the African black beans (Griffonia simplicifolia). In the human organism it is produced from tryptophan. During the reaction of decarboxylation 5-HTP and aromatic L-amino acid decarboxylase (AAAD) take part in the production of serotonin, which is a key neurotransmitter responsible for mental comfort. 5-hydroxytryptophan is a popular ingredient of dietary supplements for lowered mood. It is also an efficient support for the people who have trouble sleeping and those who want to lose weight.
EGCG | Camellia sinensis
  • extract 50% EGCG (500 mg / 2 caps.)
EGCG is a strong antioxidant that can be found in green tea. The main property of EGCG is the ability to deactivate the AAAD enzyme that transforms L-DOPA in the digestive system. It also inhibits the activity of the COMT enzyme that breaks key neurotransmitters, such as: dopamine, adrenaline and noradrenaline. Because of that, EGCG helps to regulate the levels of neurotransmitters in the brain. At the same time, it supports memory and focus, while protecting the nervous system from harmful factors, including free oxygen radicals and inflammation. What is more, this compound facilitates metabolism in cells by increasing the biogenesis in mitochondria.

Ingredients of Melissa BioSynergy™:

Lemon balm | Melissa officinalis
  • extract 10% rosmarinic acid (500 mg / 2 caps.)
Lemon balm is a plant widely known all over the world for its ability to reduce anxiety. The natural compounds found in this herb are ursolic acid and rosmarinic acid. Those substances catalyze the reaction of conversion of L-glutamate to GABA. The other active compounds can modulate the activity of GABA receptors. That is why lemon balm extract helps to reduce tension and other symptoms of stress. Melissa officinalis also helps to fall asleep faster if taken in the evening while providing better regeneration during the sleep - both mental and physical.
Yuan Zhi | Polygala tenuifolia
  • extract 20:1 (300 mg / 2 caps.)
Polygala tenuifolia is an herb that occurs in the widespread areas of Asia. It can be found mostly in China, Mongolia and Russia. It is very popular in Traditional Chinese Medicine, where it is known as Yuan Zhi. However, natural Japanese medicine as well as Ayurveda also use this plant. Polygala supports cognitive functions and improves intellectual performance. The active compounds found in this herb increase the activity of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). This way, polygala extract affects the processes of neurogenesis and neuroplasticity that lead to creation of new nerve cells and connections between them. Those processes are especially important in terms of learning abilities and memory. What is more, polygala stimulates the activity of choline acetyltransferase (ChAT) - an enzyme that transforms choline into acetylcholine - a neurotransmitter responsible mainly for proper information exchange between neurons.

Ingredients of Valerian BioSynergy™:

Valerian
  • extract 0.8% valerenic acid (500 mg / 2 caps.)
Valerian (Valeriana officinalis) is a very popular herb that commonly occurs in moist areas of Europe, Asia and North America. It exhibits numerous health benefits that have spot interest of ancient medical experts, including the Greek “father of medicine” Hippocrates and a renowned doctor - Pedanius Dioscorides. It is used primarily as a sedative and anxiolytic ingredient as it stimulates the activity of GABA - the main inhibitory neurotransmitter. Besides that, valerian acts as a diastolic - it helps to relax smooth muscles in the stomach and the intestines. The main biologically active compounds of valerian are: valeric acid, isovaleric acid, myristicin acid.
Passion flower | Passiflora Incarnata
  • extract 20% flavonoids (300 mg / 2 caps.)
Passiflora is an herb that comes from the North and Central Americas where it has been used by local Indian tribes for thousands of years. The European colonizers brought passiflora to the Old Continent in the 18th century. This herb has become so popular because it regulates the activity of serotonin, the so-called “happiness hormone”, as well as GABA - a key neurotransmitter responsible for stress resilience that reduces the intensity of emotional reactions. Passiflora supplementation supports better sleep and helps to relax. It also increases libido since active compounds found in this plant improve testosterone production. The most important of those compounds are indole alkaloids and the essential oil which is a composition of 150 different ingredients.

SLEEP-BOX™ Herbal Synergy formula properties

Improves sleeping quality: Insomnia can have many causes, but they all come down to one thing: inadequate activity of neurotransmitters responsible for inhibiting the nervous system, which affects the whole body. SLEEP-BOX™ Herbal Synergy can help to improve that balance. Its ingredients support those areas of neuroactivity that are key to falling asleep and sleeping without issues. One of them is controlled by adenosine. The levels of this compound tend to be lower in the morning and then rise during the day to reach a maximum in the evening, so it can induce drowsiness. Melatonin has a similar effect – its secretion intensifies after dusk and is a signal for the body to fall asleep. But this feeling of drowsiness alone wouldn’t be enough – after all, it is nearly impossible to rest feeling anxious or mentally agitated. Therefore, it is necessary to ensure proper activity of GABA – the main inhibitory neurotransmitter. It blocks unnecessary and redundant nerve impulses, preventing overstimulation of the brain, which ultimately helps to calm down the body as well. The ingredients of this formula improve the activity of adenosine (often disrupted by caffeine), stimulate production of melatonin (reduced due to artificial light sources, e.g. screens of electronic devices) and enhance the effects of GABA (which can be lowered because of chronic stress). Consequently, they help to relax the body and calm the nerves down, which makes the sleep more efficient. They do not disturb the natural rhythm of sleep phases REM and NREM. It is particularly important because both of them have different functions. During the REM phase, memory consolidation occurs while NREM promotes secretion of growth hormone, stimulating recovery processes. Our formula will help to rest even after the most demanding day and help to get up refreshed, ready for new challenges.

Improves stress resilience: One of the most common causes of sleep problems is a long-term exposure to stress. In terms of proper neural activity, that situation can disrupt the effects of GABA in particular. This brain chemical controls bodily responses to stress. It influences the hypothalamic-pituitary-adrenal (HPA) axis – a functional system that gets triggered in stressful situations. Stimulation of the HPA axis results in the secretion of large amounts of cortisol, which is responsible for many of the negative effects induced by stress. The ingredients of SLEEP-BOX™ Herbal Synergy support GABA activity. They intensify the production of the GABA-A receptor subunit. They help to exert better effects on specific cells after the molecules of this brain chemical attach to receptors. These ingredients can interact with GABA receptors similarly to their natural ligand. In addition, they inhibit enzymatic breakdown of GABA molecules and their removal from synapses. In effect, this compound can influence the nervous system for a longer time and with more pronounced results. The measurable changes that these herbal extracts provide are the reduction of blood pressure, heart rate or cortisol levels. This shows that the body calms down. Hence, our preparations improve stress resilience and alleviate the unpleasant impact of stress on the body.

Supports well-being: It is very hard to enjoy a peace of mind when we don’t get a proper amount of rest. On the other hand, we may have real trouble sleeping when our mind is racing or uneasy. That is why we designed our formula so it can affect these aspects of our lives as well. The ingredients of SLEEP-BOX™ Herbal Synergy include the direct precursor of serotonin, that quickly reaches the nervous system, where it is transformed into a fully functional neurotransmitter. Other herbal extracts found in these preparations ensure that serotonin molecules remain in the synapses for a longer time, so they can interact with specific receptors. They are able to inhibit the activity of proteins that transport this substance back to the cell. Besides that, they reduce the activity of enzymes that break down dopamine and serotonin, which is particularly important because both these compounds have key roles in the organism. The first one is released during the stimulation of the reward system in the brain, thus it is responsible for motivation and satisfaction. Serotonin, on the other hand, helps to experience mental well-being. Moreover, the ingredients of this formula enhance the activity of GABA, which essentially relaxes the body, calms down the brain and facilitates emotional stability. All these effects make our extracts a great choice for psychological wellness.

Supports the nervous system: If we don’t get enough sleep, we may experience fatigue – not only physically but also in terms of mental well-being. That’s because a proper amount of sleep is essential for the brain to regenerate. Our formula can come in handy in this field as well because its ingredients support the development and recovery of the central nervous system. They stimulate the secretion of neurotrophins – molecules capable of intensifying neurogenesis and neuroplasticity, i.e. the processes that lead to formation of new nerve cells and connections between them. These mechanisms are crucial for efficient functioning of the nervous system and support cognitive abilities. Herbal extracts of this formula help to counteract free radicals that in excessive amounts can be toxic to neurons and potentially damage their structures. These ingredients also lower the risk of forming beta-amyloid deposits, the accumulation of which is one of the main factors that promote development of Alzheimer’s disease. And since they have a positive effect on the natural rhythm of sleeping, they help to consolidate memory, so it might be stored for a longer time. What is more, SLEEP-BOX™ Herbal Synergy stimulates the production and inhibits the breakdown of acetylcholine – a neurotransmitter that is actually crucial for concentration, quick and clear thinking as well as effective information acquisition. All in all, this natural formula is a great choice for an overwhelmed mind that needs to recover.

SLEEP-BOX™ Herbal Synergy formula specification

Formula Valerian BioSynergy™

TYPE OF PRODUCT:
  • preparation in gelatin capsules
RECOMMENDED DOSE:
  • 2 capsules daily unless advised otherwise by a professional
INGREDIENTS:
[800 mg / 2 caps.]
PACKAGING:
  • airtight PET bottle 100 ml / 120 ml
INTENDED USE:
  • nutrition, neuroregulation, herbal medicine
LEGAL STATUS:
  • ingredient admitted to trading in the EU and the US

Formula 5-HTP BioSynergy™

TYPE OF PRODUCT:
  • preparation in gelatin capsules
RECOMMENDED DOSE:
  • 2 capsules daily unless advised otherwise by a professional
INGREDIENTS:
[700 mg / 2 caps.]
PACKAGING:
  • airtight PET bottle 100 ml / 120 ml
INTENDED USE:
  • nutrition, neuroregulation, herbal medicine
LEGAL STATUS:
  • ingredient admitted to trading in the EU and the US

Formula Melissa Biosynergy™

TYPE OF PRODUCT:
  • preparation in gelatin capsules
RECOMMENDED DOSE:
  • 2 capsules daily unless advised otherwise by a professional
INGREDIENTS:
[800 mg / 2 caps.]
PACKAGING:
  • airtight PET bottle 120 ml
INTENDED USE:
  • nutrition, neuroregulation, herbal medicine
LEGAL STATUS:
  • ingredient admitted to trading in the EU and the US

SLEEP-BOX™ Herbal Synergy usage

Formula Valerian BioSynergy™

CAPSULES PER SERVING:
  • 2
SERVINGS PER DAY:
  • 1 – 2
BEST ABSORPTION:
  • with food
WHEN TO USE:
  • before bedtime
OPTIMAL CYCLE DURATION:
  • 4 weeks of using – 2 weeks of break

Formula 5-HTP BioSynergy™

CAPSULES PER SERVING:
  • 2
SERVINGS PER DAY:
  • 1 – 2
BEST ABSORPTION:
  • without a meal
WHEN TO USE:
  • during the day / before going to sleep
OPTIMAL CYCLE DURATION:
  • 4 weeks of using – 2 weeks of break

Formula Melissa Biosynergy™

CAPSULES PER SERVING:
  • 2
SERVINGS PER DAY:
  • 1 – 2
BEST ABSORPTION:
  • with food
WHEN TO USE:
  • in the evening / before bedtime
OPTIMAL CYCLE DURATION:
  • 6 weeks of using – 2 weeks of break

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.