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SAM-e + TMG is a synergistic preparation that comprehensively supports the whole organism by protecting it from free radicals and other toxic substances. It also enhances muscle gain and regeneration while increasing the level of energy. By regulating the activity of key neurotransmitters, this combination helps to improve and stabilize the mood.


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SAM-E + TMG formula properties

SAM-e with TMG make a synergistic combination of two bioactive amino acids which, in their basic form, are naturally produced by the human body. Both compounds support detoxification processes during which toxins, free oxygen radicals and other harmful substances are neutralized. This preparation has a positive effect on liver cells, protecting them from damage. Moreover, it contributes to the enhanced production of glutathione – one of the strongest natural antioxidants. In the context of neuroregulation, it is worth knowing that both components modulate neurotransmitters – they support the activity of serotonin, dopamine and GABA which helps to improve general mood and the level of energy. The combination of these two compounds allowed us to prepare a product that not only protects the body from harmful substances but also effectively supports its functioning.

SAM-E + TMG is a preparation that comprehensively supports body detox and its regeneration. It is especially suitable for people who want to keep their liver in a good condition. It can also be used as a remedy for the “next day’s syndrome”. In addition, due to its antidepressant properties, it is often used by people who are struggling with a low mood. Because of the anabolic properties, it will also be a good choice for those who exercise intensively.

Ingredients of SAM-e NooSynergy™ formula:

SAM-e | S-Adenosyl methionine
  • 400 mg / 2 caps.
S-Adenosylmethionine (SAM-e) is a natural compound that acts as a nootropic and antioxidant. In terms of chemistry, it is a derivative of adenosine and methionine. This substance is key to many chemical reactions that occur in the human body. It is also quite important for the nervous system because it regulates neurotransmitters. SAM-e supplementation raises mental comfort because this compound stimulates receptors of serotonin - the so-called “happiness hormone” - but also dopamine that activates the reward system in the brain. SAM-e supports acetylcholine activity, and in effect, provides better memory and attention.
TMG | Trimethylglycine
  • 600 mg / 2 caps.
Trimethylglycine is a methyl derivative of glycine that exhibits detoxifying and neuroprotective properties. TMG supports the conversion of homocysteine into methionine. This, in turn, is an important stage in the process of glutathione production. Thus, TMG takes part in the production of the strongest natural antioxidant. It also stimulates growth hormone secretion, increasing physical capabilities of the body, especially during a demanding physical activity.

SAM-E + TMG formula benefits

Cleanses the body: Scientific research has shown that S-adenosylmethionine exhibits a positive effect on the liver. It protects this organ from damage that might be caused by certain toxins. It also supports the functions of the liver cells, as it stimulates the action of mitochondria that are the main energy suppliers for the cells. This significantly increases the capacity of hepatocytes. Trimethylglycine, on the other hand, contributes to the neutralization of homocysteine – an amino acid that is produced as a byproduct  of protein digestion. Its high concentration in blood is a risk factor for atherosclerosis, myocardial infarction and a stroke. TMG and SAM-e also participate in the production of glutathione – a peptide with strong antioxidant properties. This way, these two compounds help to protect the body from toxins and free radicals.

Supports positive attitude: Serotonin is sometimes referred to as a “happiness hormone” as it has an important role in regards to mental comfort. Its deteriorated level in the central nervous system results in a significant and prolonged reduction of general mood which is usually accompanied by negative thoughts and emotions. Research has revealed that sometimes it might be related to a decreased concentration of SAM-e. During the clinical trials it has been demonstrated that supplementation with this amino acid results in an increased serotonin activity within two weeks. Proper activity of trimethylglycine is no less important since this compound is involved in the regulation of serotonin as well as dopamine and GABA activity which is also important for mental health. All these effects make SAM-e and TMG a great support for one’s mental comfort.

Improves physical performance: Scientific research has shown that trimethylglycine stimulates the release of growth hormone and insulin-like growth factor (IGF-1). These two hormones stimulate the expansion and regeneration of muscle tissue. Besides that, TMG protects the myocytes from damage during intense physical effort. S-adenosylmethionine stimulates dopamine production. This neurotransmitter determines the appropriate level of energy and increases motivation. Hence, the combination of SAM-e and TMG facilitates exercising and supports regeneration after workout.

SAM-E + TMG formula specification


  • preparation in gelatin capsules
  • 2 capsules daily unless advised otherwise by a professional
[1000 mg / 2 caps.]
  • airtight PET bottle 100 ml / 120 ml
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

SAM-E + TMG formula usage

  • 2
  • 1 – 2
  • without food
  • in the morning / during the day
  • 4 weeks of using – 2 weeks of break

SAM-E + TMG formula stacking

Liver support and body cleansing:
Serotonin balance and mood support:
Physical stamina support:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.