Improves the condition of the nervous system: It is a common knowledge that chronic stress has a bad influence on the nervous system – it might impede clarity of thought and disturb intellectual capacity. The ingredients found in our formula counteract those unfavorable effects. They increase the activity of acetylcholine – a neurotransmitter that is crucial for efficiency of cognitive functions, particularly memory, attention and the ability to connect the facts. Lion’s Mane stimulates the production of acetylcholine. Brahmi, Gotu Kola, Ashwagandha and Reishi inhibit the breakdown of this neurotransmitter. On the other hand, Ginkgo biloba increases its density within the prefrontal cortex – a brain region that is particularly active during intellectual operations. Ginkgo also modulates the activity of glutamate – the neurotransmitter that plays an important role in long-term potentiation (LTP) that is a basic process governing information acquisition. Besides that, this herb improves blood flow within the arteries that supply oxygen and nutrients necessary for the efficient work of the brain. The ingredients of our formula support the development and regeneration of the brain, particularly by affecting the activity of NGF and BDNF – the proteins that stimulate the process of neurogenesis (formation of new nerve cells) and neuroplasticity (creating connection between neurons). The neuroprotective properties of those herbs are also very important. Lion’s Mane reduces the accumulation of beta-amyloid that might be harmful for the neurons that produce acetylcholine. Brahmi, on the other hand, has the ability to chelate heavy metals facilitating their removal. It has also been proven that it might slow down the changes that occur due to the aging process. Brahmi, Ashwagandha and Ginkgo biloba neutralize free oxygen radicals and protect delicate cellular structures from damage. All those properties make this combination of six natural ingredients an excellent support for a fatigued brain.

Increases stress resilience: The reaction of the body to stressful stimuli is regulated mostly by the hypothalamic-pituitary-adrenal (HPA) axis. Hypothalamus can be considered a mediator between the nervous system and the endocrine system. Based on the signals that come from the brain, it is able to activate the flow of specific hormones. One of them is corticoliberin that stimulates the pituitary gland to secrete corticotropin. This last hormone takes part in the production and release of cortisol – the so-called “stress hormone” – whose excessive level over a long time can lead to many negative effects usually associated with chronic stress. The HPA axis activity is regulated by many neurotransmitters but the most important one in that regard is GABA that has a strong influence on the intensity of stress resilience and helps to stabilize emotions. Research indicates that the ingredients of our formula effectively regulate GABA activity but also affect the release of cortisol. Gotu Kola is able to increase the amount of an enzyme involved in the production of this neurotransmitter by up to 40%! Brahmi and Ashwagandha improve the density of GABA receptors in the synapses. At the same time, Reishi affects the receptors but in a slightly different way. Since it contains active compounds that act as antagonists of benzodiazepine receptors (that are a part of GABA receptors and stimulate the activity of this neurotransmitter), it is able to block them. Because of that, more receptors are present on the neuron surface which helps to improve the activity of GABA. All these effects inhibit the HPA axis and thus reduce the intensity of stress reactions. Lion’s Mane and Ginkgo biloba do not affect the activity of GABA directly. However, the scientists suggest that Lion’s Mane might have some influence on the hippocampus – a brain region which is the most active when we are processing memories and emotional reactions. Ginkgo, on the other hand, reduces cortisol release during stressful events and helps to control blood pressure. Therefore, a combination of those 6 ingredients will help to stay strong in the face of challenges that are typical for the modern world.

Supports a good mood: There are two neurotransmitters that can instantly be associated with a positive attitude: dopamine and serotonin. The first one is responsible for the activity of the reward system that is related to the feeling of pleasure and motivation. The second one is commonly known as a “happiness hormone” as it usually induces mental comfort and a sense of joy. The ingredients of our formula support the activity of those two neurotransmitters. Brahmi upregulates tryptophan hydroxylase – an enzyme that catalyzes the first stage of serotonin production. It has been proven that this herb might increase the level of this neurotransmitter particularly in the hippocampus – a brain region that is involved in the processing of memory and emotions. Ginkgo and Ashwagandha sensitize serotonin receptors, hence this compound can affect the neurons more efficiently. Besides that, Ginkgo biloba helps to increase dopamine levels in the prefrontal cortex that is important in terms of emotional reactions. Gotu Kola and Lion’s Mane are also able to regulate the density of dopamine and serotonin. The scientists believe that Lion’s Mane may act as a mild inhibitor of MAO – the enzyme that breaks down the molecules of those neurotransmitters. That would mean that this herb can improve their ability to affect specific receptors. Anyway, each ingredient has a positive effect on BDNF and NGF – the compounds that stimulate neurogenesis and neuroplasticity. It has been proven that during chronic stress and/or lowered mood their production is disrupted. Thus, the stimulation of those endogenous neurotrophic factors is of great importance for mental health. The results of clinical tests indicate that all the herbs that can be found in our formula support psychological well-being and can possibly improve perceived quality of life.

Supports general health condition: The ingredients of our formula include adaptogenic herbs that positively affect both physical and mental health. Chronic stress can put a lot of strain on the immune system. Reishi and Lion’s Mane help to increase the number and activity of white blood cells that are the main line of defense in the fight against infections. Some of those cells include: lymphocytes B and T, macrophages, dendritic cells (those presenting antigen) and the NK cells that are capable of destroying tumors. Ashwagandha has a similar effect but also slows down the development of various pathogenic microbes. In addition to that, all those ingredients combined can reduce inflammation which might be particularly important during chronic stress. But prolonged exposure to stressful stimuli is also harmful for the circulatory system – high levels of cortisol may increase blood pressure. Ginko biloba and Gotu Kola can counteract those effects. The first herb is particularly effective as it relaxes muscles of blood vessels. Together with Lion’s Mane, it reduces the aggregation of blood platelets which helps to prevent blood clots and improves blood flow, facilitating the supply of oxygen and nutrients. Moreover, those two herbs might have a positive impact on atherosclerosis prevention. Foam cells – a special type of macrophages – are able to ingest cholesterol and attach to the walls of blood vessels. Over time, those fat deposits can transform into artery plaques leading to atherosclerosis. Ginkgo biloba and Lion’s Mane inhibit the development of foam cells and thus help to keep the circulatory system in a good condition. Ashwaganda and Reishi may lower cholesterol level in blood which is also a key point of atherosclerosis prevention. Besides that, Reishi, Lion’s Mane and Brahmi support the natural detoxification process. Healthy kidneys and the liver are crucial to neutralize toxic substances. Our herbs protect those two organs from harmful factors, including oxidative stress and excessive inflammation. Combined properties of Ashwagandha and Brahmi can be particularly valuable for mature ladies since these two Ayurvedic herbs alleviate the symptoms of menopause. On the other hand, gentlemen might appreciate the fact that Ashwagandha increases testosterone level but also improves satisfaction from sexual activity, which is most likely related to reduced stress. Ashwagandha and Brahmi can reduce fatigue, both in physical and mental sense. This way, all the ingredients of our formula work synergistically, improving general condition and quality of life.