Pyritinol | NeuroPyridoxine™

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Pyritinol is a derivative of vitamin B6 with a significant nootropic effect. It positively affects the nervous system, improving intellectual capacity and concentration. Pyritinol can also be used as a support for a general mood as it helps to stabilize emotional reactions. Besides that, it enhances natural detoxification processes that occur in the body and reduces hangovers.


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Pyritinol | NeuroPyridoxine™

Properties: Pyritinol cannot be found in nature because it is obtained using laboratory methods. It was invented in the 1960s so it’s not brand-new. Since then, scientists have conducted a lot of studies in order to check the most important properties of this substance. Although they have not discovered all the benefits of using pyritinol, we still know quite a lot about it. 

We know for example that pyritinol helps to increase the level of the key neurotransmitters, including acetylcholine that, to a large extent, is responsible for the proper functioning of cognitive functions – it improves the speed of information processing and the level of concentration. Because of that, pyritinol is perfect as an ingredient of dietary supplements that have a nootropic effect – those that support mental processes. 

However, it is hard to have a clarity of mind when we lack the energy and motivation to act. Without the appropriate level of energy, every intellectual effort usually does not bring any satisfactory results. That is why it is worth considering: which neurotransmitter acts as a stimulant and helps to maintain the will to act? Bingo! It’s dopamine. It turns out that pyritinol effectively stimulates the secretion of dopamine in the nervous system and due to that we are more likely to get that energy. Besides, our ability to focus increases as well which provides better performance at work. 

What is more, an increased activity of dopamine leads to a better mood. In this context, we cannot forget about one more neurotransmitter – serotonin. This neurotransmitter is often called the “happiness hormone”. And guess what! Pyritinol also stimulates the production of serotonin providing increased psychological comfort. On top of that, it has been proven that this synthetic compound positively affects general health and speeds up “cleansing” processes, i.e. removal of harmful substances. Scientists have proven that by regular intake of pyritinol we contribute to antioxidative abilities of our organism and more easily get rid of free radicals that damage cells of our body. 

There is ongoing research on use of pyritinol to treat the symptoms of alcohol poisoning. Despite the fact that there is study data that confirms its effectiveness in this area, we still have to wait for more accurate results. Without question it is worth keeping a close watch on scientists’ work in this field. Anyway, there is no doubt that this synthetic compound has a number of scientifically-proven properties which everyone can find satisfactory.

Occurrence: Pyritinol is not present in nature. It is obtained by laboratory synthesis. This derivative of vitamin B6 was synthesized for the first time in 1961 at the labs of pharmacological company Merck KGaA and it was patented in the same year.

Biochemistry: Pyritinol (pyridoxine disulphide) is an organic chemical compound that is a semi-synthetic derivative of pyridoxine. It is obtained by merging two molecules of vitamin B6 (pyridoxine) with disulfide “bridge”. Pyritinol is easily soluble in water. In our body it helps to increase the level of dopamine, acetylcholine and GABA. In addition, it helps glucose to cross the blood-brain more quickly, decreases the excessive production of lactic acid and increases the resistance of brain tissue to hypoxia. Besides, it supports the mechanisms of transformation of toxins that usually occur in the liver.

Fun fact: Pyritinol might be a remedy for hangovers even though there are few reports on this issue in the scientific literature. There is only one experimental study with humans. The effectiveness of pyritinol in the aspect of hangovers might be connected to inhibition of prostaglandins. However, we need more studies that will explain this mechanism.

How does Pyritinol | NeuroPyridoxine™ work?

Improves intellectual performance: Dopamine is a stimulating neurotransmitter that is responsible for maintaining the optimal level of physical and mental energy. It is also crucial for the ability to focus as well as for abstract thinking, working memory and multitasking. Vitamin B6 acts as a cofactor in the synthesis of dopamine and, that way, it increases its level in the central nervous system. And because pyritinol is a derivative of vitamin B6, it works in the same way. By increasing the activity of dopamine, it has a positive effect on cognitive functions. In addition, pyridoxine stimulates the production of GABA – a neuromodulator that prevents excessive activation of the nervous system. Pyritinol works similarly and helps to improve the stability of concentration. Increased energy and motivation levels result in the improvement of intellectual performance.

Supports the nervous system: Pyritinol was developed mainly in order to support the central nervous system when it is weakened and the cognitive functions are disrupted. This derivative of pyridoxine promotes metabolism of neurons, e.g. increasing glucose usage by those cells. It also facilitates signal transduction inside of neurons. Studies are being carried out to discover if pyritinol may be used during recovery after neurologic diseases. It has been proven that it facilitates regeneration of neurons that produce acetylcholine – a neurotransmitter that is crucial for the efficient remembering and recalling of information. It may also directly increase the activity of acetylcholine. That way, pyritinol improves data processing in the brain and supports cognitive functions.

Supports good mood: Pyridoxine, and most likely pyritinol, is a cofactor of enzyme that catalyzes production of serotonin – a neurotransmitter that is responsible for a good mood. According to research evidence providing this cofactor may contribute to an increased production of serotonin. No less important is the fact that pyritinol stimulates production of dopamine. This neurotransmitter is released in response to activation of the so-called reward system in the brain that induces the feeling of pleasure. Increased activation of those two neurotransmitters simply contributes to a better mood. Intensified production of GABA, also caused by pyritinol, helps to stabilize mood and supports resistance to stress.

Helps to detoxify the organism: Scientific reports indicate that pyritinol might be an effective support for the natural mechanisms than cleanse the body of the excess of free radicals. It is worth noting that this form of vitamin B6 provides anti-inflammatory effects. Thus, it might prevent the development of chronic inflammation that is particularly dangerous to different tissues and cellular structures, including DNA. There are studies on the use of pyritinol to soothe the symptoms of alcohol poisoning. Their results indicate that it can reduce damage caused by the products of ethanol metabolism.

Pyritinol | NeuroPyridoxine™ product specification


  • powdered raw ingredient
  • pyritinol >99%; pharmaceutical quality
  • steel measuring tool 0.10 ml ~ 75 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

How to use Pyritinol | NeuroPyridoxine™?


  • 100 – 200 mg
  • 1 – 3
  • without food
  • in the morning / during the day
  • 6 weeks of using – 2 weeks of break

How to stack Pyritinol | NeuroPyridoxine™?

To improve intellectual performance:
To support the nervous system:
To improve general mood:
To support detoxification:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.