PRL-8-53 | Pirotropil™

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PRL-8-53 is a nootropic compound that was developed in the second half of the twentieth century. It helps to increase the activity of dopamine and acetylcholine which brings positive effects in terms of memory and cognitive functions. Moreover, PRL-8-53 has been found to boost motivation and willingness to act which makes it a great support for those who struggle with procrastination.


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PRL-8-53 | Pirotropil™

Properties: PRL-8-53 is definitely an unusual name for a dietary supplement. What lies behind this string of letters and numbers straight from a spy movie? It turns out that quite a bit. PRL-8-53 was synthesized in the laboratory and its main function was supposed to be an improvement of the functioning of the nervous system. One must admit that it works very well in this field. It slightly stimulates our body because it speeds up metabolic processes that occur in the organism. Most important is, however, its impact on the neurotransmitter balance. PRL-8-53 acts on receptors for dopamine. As a result, it provides a boost of energy, so we are more likely to undertake new assignments. No wonder that PRL-8-53 was used as a substance that supports motivation. Some have suggested that it can be beneficial for those who deal with procrastination – the action of postponing some tasks. It was proven that due to increased dopamine activity, PRL-8-53 helps to take care of the optimal level of motivation. 

However, this compound has a much broader scope of action within the central nervous system. It is also of special importance for cognitive functions, especially for concentration and memory. Curiously, mainly for the long-term memory. That is the reason why PRL-8-53 is a valuable support for those who are always forgetting something. It was proven that taking this substance positively affects the ability to absorb information. We therefore have a supplement that affects the activity of dopamine and simultaneously enhances the functioning of the brain by increasing the transmission of nerve impulses through receptors for acetylcholine.

Occurrence: PRL-8-53 is not present in nature. Instead, it is obtained by laboratory synthesis. This compound was first synthesized by a neuropharmacologist Nikolaus R. Hansl at Creighton University in Omaha (Nebraska, the United States).

Biochemistry: PRL-8-53 is an organic chemical compound that is a derivative of benzoic acid and phenylamine. Its mechanism of action is not entirely clear. It is known, however, that it helps to speed up the metabolism, especially within the nervous system where it increases the consumption of oxygen and glucose, and also accelerates the flow of blood. What is more, it contributes to the increase of activity of acetylcholine – a neurotransmitter that is responsible for a good mood and motivation.

Fun fact: PRL-8-53 got its slightly mysterious and unusual name from the Pacific Research Labs (PRL) – an organization that was the first patent holder for this compound.

How does PRL-8-53 | Pirotropil™ work?

Increases the level of energy: Research studies indicate that PRL-8-53 contributes to the increase of metabolic rate in the whole organism. This effect is especially visible within the central nervous system. Improved blood flow and increased consumption of oxygen and glucose in this area are the evidence of much more efficient work of neurons under the influence of PRL-8-53. This effect is accompanied by enhanced activity of dopamine – a stimulating neurotransmitter which basically works just like the gas in your car. PRL-8-53 stimulates receptors for dopamine and that way it helps to feel a burst of energy.

Improves attention: One of the mechanisms of action of PRL-8-53 is stimulating the receptors for dopamine exactly like their natural ligand. Dopamine is a key neurotransmitter for concentration. Increasing its activity improves the ability to focus at any object and to smoothly transfer attention from one topic to another. This is the fundamental part of multitasking. Due to its impact on cognitive functions, PRL-8-53 facilitates the learning process.

Supports memory: PRL-8-53 stimulates the activity of acetylcholine. This neurotransmitter works in our brain just like a gas pedal in the car. It is responsible for the speed of information processing and for tying up the previously assimilated information with a new one. The results of scientific studies helped to establish that molecules of PRL-8-53 interact with the receptors for acetylcholine and increase the transmission of nerve impulses. During the clinical trials it was proven that this compound helps to improve the assimilation of information by up to 150% – patients who supplemented this compound had better results in a test than people from a control group. What is more, that remembered information could have been repeated even after a week. This is the confirmation that PRL-8-53 has long-lasting effects.

Supports motivation: Dopamine is a neurotransmitter responsible not only for the energy level and concentration but also for the motivation to act. When dopamine activity is too low, it results in tiredness and distraction, but also the tendency to procrastinate increases. PRL-8-53 directly affects dopamine receptors, stimulates them and thus works just like this neurotransmitter. That way it helps to find motivation and to fight the urge to postpone important tasks to unspecified “later”.

PRL-8-53 | Pirotropil™ product specification


  • powdered raw ingredient
  • PRL-8-53 >99%; pharmaceutical quality
  • yellow micro-spoon ~2 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

How to use PRL-8-53 | Pirotropil™?


  • 2 – 5 mg
  • 1 – 2
  • without food
  • in the morning / during the day
  • 2 – 3 days a week

How to stack PRL-8-53 | Pirotropil™?

To increase energy level:
To improve attention:
To improve memory:
To increase motivation:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.