Decreases nervousness: GABA is a main inhibitory neurotransmitter in the brain. Its receptors are present in nearly all neurons as they have an important function in the nervous system. Their role is to prevent overstimulation of the mind and the whole body. It helps to cope with the stress by mitigating the physiological response to stressors. Research evidence demonstrates that active compounds of milkwort increase the activity of GABA. They stimulate the production of its gamma receptors subunit GABA-A and directly affect those receptors, similarly to their natural agonist. Therefore, Yuan Zhi supplementation helps to calm down and relax.

Improves cognitive capacity: Both traditional Chinese medicine and Japanese Kampo have used milkwort to counteract the aging-associated degradation of cognitive abilities. Results of modern research confirmed its nootropic properties. As it turns out, its active compounds stimulate secretion of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) – hormones that are crucial for neurogenesis and neuroplasticity. These are the processes in which new neural cells and connections between neurons are formed. This is the foundation of the central nervous system that enables efficient memorizing and the ability to learn new skills. What is more, the extract of milkwort increases the available levels of acetylcholine – a neurotransmitter crucial for memory and concentration. This is achieved in two ways. First, it stimulates the activity of choline acetyltransferase (ChAT) – an enzyme that transforms choline into acetylcholine. Second, it inhibits the activity of acetylcholinesterase (AChE) that is responsible for acetylcholine decomposition.

Counteracts insomnia: Results of multiple scientific studies show that the extract of thin-leaf milkwort efficiently induces relaxation and makes falling asleep easier. It also helps to prolong the sleep duration, while maintaining its natural properties. For instance, an EEG study confirmed that the administration of P. tenuifolia extract does not alter the physiological rhythm of REM and NREM sleep phases. Instead, it deepens sleep and brings about an increase in its regenerative properties. The source of these effects is higher GABA activity. Active compounds of milkwort take part in production and stimulation of GABA receptors. Moreover, Yuan Zhi is able to activate adenosine neurotransmission, which supports falling asleep.

Supports good mood: Research evidence points to the positive effect of milkwort’s root on mental health. Its active compounds inhibit the activity of serotonin transporter protein (SERT), thereby decreasing the reuptake of serotonin. In this way, molecules of this neurotransmitter are allowed to remain in synaptic clefts and influence their receptors longer. Additionally, Polygala has the ability to downregulate the activity of monoamine oxidase (MAO) – an enzyme that decomposes molecules of dopamine and serotonin. These two neurotransmitters are crucial for maintenance of a positive mood and the feeling of inner contentment. Yuan Zhi effectively supports their activity, which benefits psychological well-being.