Nefiracetam | Nefitropil™

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Nefiracetam is an interesting member of the racetam group that consists of compounds with nootropic effects. It facilitates blood flow in the brain, therefore supporting cognitive efficiency, attention and memory. Besides that, nefiracetam stimulates the activity of neurotransmitters responsible for emotional stability and stress resilience.


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Nefiracetam | Nefitropil™

Properties: If you are looking for a modern and safe nootropic compound made in Japan, look no further! Nefiracetam was created thanks to the commitment of Japanese scientists who aimed at development of an efficient compound from the family of racetams. Their efforts were fruitful and thus nefiracetam joined the team that already had some strong players such as aniracetam, oxiracetam or coluracetam. Similar to other racetams, it has nootropic properties. This means that it supports the functioning of the brain, particularly its concentration and memory systems. Additionally, it enhances the learning process by stabilizing the pathways connecting neurons. Thus, thanks to this mechanism, remembering becomes easier. 

However, nefiracetam has some distinctive features that make it stand out from other racetams. Foremostly, it affects the GABA receptors much stronger. Thereby, it not only supports cognitive skills but also helps to quiet down unnecessary emotions and makes dealing with stress consequences easier. Scientific evidence actually backs up the claim that nefiracetam supplementation significantly improves the mood. 

Combination of these properties makes nefiracetam an excellent choice for those who wish to combine the nootropic effects of racetam with inhibitory influence of GABA neurotransmitter molecules. Let’s not forget that nefiracetam is also effective as a substance that protects nerve cells against inflammation. For this reason, it can increase our intellectual abilities and at the same time protect delicate cellular structures from damage.

Occurrence: Just like other racetams, nefiracetam does not occur in nature. Instead, it is chemically synthesized in laboratories. It was first developed in the 90s by Japanese scientists.

Biochemistry: Nefiracetam (DM-9384) is an organic chemical compound classified as a racetam. As all compounds in this group, its molecule contains a 2-pyrrolidone ring, a derivative of γ-aminobutyric acid (GABA). It is analogous to piracetam, however structurally it resembles aniracetam. This fat-soluble compound easily crosses the blood-brain barrier. Within the central nervous system it stimulates the activity of the main excitatory neurotransmitter – glutamate. Moreover, it increases the density of choline, a crucial substrate for the synthesis of acetylcholine – another excitatory neurotransmitter. Nefiracetam is the only racetam that exhibits high affinity to GABA-A receptors. It also contributes to the improvement of blood flow in the vessels supplying the brain with nutrients and oxygen. Last but not least, it prevents premature cell death within the nervous system.

Fun fact: Up to this day scientists discovered 17 compounds that belong to the group of racetams. Besides nefiracetam the group includes popular nootropic substances such as: aniracetam, oxiracetam or coluracetam. The other interesting examples are brivaracetam and omberacetam (commonly known as noopept).

How does Nefiracetam | Nefitropil™ work?

Improves intellectual performance: The phenomenon of long-term potentiation (LTP) is fundamental for the process of information acquisition. LTP strengthens the connections between particular neurons. Two main neurotransmitters crucial in this process are glutamate and acetylcholine. Scientific evidence proves that nefiracetam increases the activity of both of them. Thereby, it stimulates the nerve cells and increases the “mental energy”. Clinical trials show that even little doses of nefiracetam intensify the process of LTP.

Supports the nervous system: Nefiracetam was developed as a result of many years of research aimed at improving the functioning of the central nervous system. Numerous studies demonstrated that it successfully increases the blood flow in the blood vessels of the brain. Therefore, neurons receive more oxygen and nutrients, which enhance their efficiency. Nefiracetam also helps to control the spread of inflammation within the central nervous system. Thus, it protects the nerve cells from damage.

Improves stress resilience: Multiple scientific studies confirmed that nefiracetam helps to deal with stressful events. This is because it can modulate the activity of GABA – the main inhibitory neurotransmitter of the brain, which is able to downregulate the activity of the central nervous system. Therefore, nefiracetam keeps the brain activity in balance. This supplement successfully reduces the negative consequences of stress, especially its most dangerous, chronic form. 

Supports good mood: Clinical trials lead to an observation that nefiracetam supplementation has a very good influence on the mood and general psychological wellness. The exact mechanism of this effect has not yet been discovered, but the scientists suspect that it is related to the GABA activity. It cannot be excluded that nefiracetam modulates the secretion of dopamine and serotonin – two neurotransmitters that regulate the subjective sense of well-being. Thus, this component might indirectly enhance their activity, simultaneously improving the mood.

Nefiracetam | Nefitropil™ product specification


  • powdered raw ingredient
  • nefiracetam >99%; pharmaceutical quality
  • PET measuring tool 0.50 ml ~ 250 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

How to use Nefiracetam | Nefitropil™?


  • 150 – 300 mg
  • 1 – 2
  • with food
  • in the morning / during the day
  • 6 weeks of using – 2 weeks of break

How to stack Nefiracetam | Nefitropil™?

To improve intellectual performance:
To support the nervous system:
To increase stress resilience:
To improve general mood:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.