Supports the nervous system: Fatigue has a negative impact on cognitive functions, whether we are talking about physical or psychological effects. The ingredients of our formula might counteract that which has actually been proven during scientific studies. Ginkgo biloba and cinnamon cassia support the development and regeneration of the brain. They improve the density of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Those two compounds stimulate neurogenesis (formation of new nerve cells) and neuroplasticity (the ability to create new connections between neurons). Rhodiola also affects neurogenesis within the hippocampus and it’s very likely that this effect is related to the fact that this herb improves serotonin level in this brain structure. Besides that, it has been proven that Rhodiola supports dopamine activity because it stimulates neurons that produce dopamine. St. John’s wort and cinnamon protect the cells from harmful effects of beta-amyloid – a naturally-occurring peptide that might be particularly dangerous for the neurons when it gets accumulated in the nervous tissue. Mucuna also has some potential in neuroprotection because it neutralizes free oxygen radicals that, in excessive amounts, may damage delicate cellular structures, including DNA. On the other hand, N-acetyl-L-tyrosine mitigates symptoms of stress and fatigue on cognitive performance. In combination, all those ingredients provide an effective support for the condition of the brain and its functions.

Supports a good mood: Dopamine is a compound that has an important role in the reward system. The release of this neurotransmitter induces feelings of pleasure and joy. That is why balanced dopamine activity is crucial for well-being and a high level of motivation. N-acetyl-L-tyrosine and L-DOPA contained in Mucuna pruriens are precursors of dopamine. Cinnamon stimulates the receptors of this neurotransmitter while St. John’s wort reduces dopamine reuptake. Moreover, Ginkgo, St. John’s wort and Rhodiola prevent molecules of this compound from deactivating too quickly. Yet, the ingredients of our formula also affect other mechanisms that may bring an improvement of mood. Serotonin, commonly known as a “happiness hormone”, is another key neurotransmitter that regulates one’s mood. Ginkgo biloba sensitizes serotonin receptors, so when this compound gets attached to neurons, it can bring stronger effects. St. John’s wort and Rhodiola are inhibitors of MAO – they reduce serotonin breakdown, allowing the molecules of this neurotransmitter to remain active for a longer time. What is more, St. John’s wort inhibits the activity of the HPA axis. This axis is a functional system that consists of three main parts: the hypothalamus, pituitary gland and adrenal glands. When we’re experiencing a stressful situation, those structures get activated and produce significant amounts of cortisol. While cortisol is a necessary hormone that regulates metabolism and immune responses, it is also related to negative consequences of prolonged stress exposure. High levels of cortisol over a longer period of time might have a bad influence on the general condition of the body. When it comes to reducing the activity of the HPA axis, GABA is probably the most effective neurotransmitter. St. John’s wort improves the activity of its receptors, thus blocking cortisol release. This way, thanks to a multidirectional influence of our ingredients, it is easier to maintain a positive attitude and a stronger stress resilience.

Improves memory and attention: Dopamine is an important neurotransmitter that affects efficiency of intellectual performance. When its activity is balanced, it has a positive effect on major cognitive functions, including attention, working memory or logical reasoning. In the central nervous system, dopamine is produced from an amino acid tyrosine. One of the enzymes called tyrosine hydroxylase acts as a catalyst in the transformation of tyrosine into L-DOPA. Then, L-DOPA reacts with an enzyme aromatic L-amino acid decarboxylase (AAAD) and ultimately becomes dopamine. Because this process is complex and involves different compounds, it is important to supply a decent amount of precursors and other compounds necessary to produce this neurotransmitter. Two ingredients of our formula can be quite helpful in that regard. N-acetyl-L-tyrosine is one of them. This acetylated derivative of tyrosine is absorbed more efficiently than the “original”, so it reaches the brain in greater amounts and can be used to produce dopamine. L-DOPA, the direct precursor of dopamine, is actually a main active compound of Mucuna pruriens. Besides that, cinnamon can affect dopamine receptors, improving their activity. Rhodiola and St. John’s wort – as inhibitors of MAO and COMT – reduce the breakdown of this neurotransmitter so it can affect the nervous system for a longer time. However, an increased activity of dopamine is not the only factor that can influence cognitive performance. St. John’s wort and Ginkgo biloba are able to stimulate the activity of another important compound – glutamate. This neurotransmitter is particularly important for the process of long-term potentiation (LTP) that is fundamental for effective information acquisition. Ginkgo biloba, possibly together with cinnamon, increases the activity of acetylcholine, especially in the prefrontal cortex where most of the advanced mental processes occur. Acetylcholine is a neurotransmitter necessary for attention skills but it also has an important role in memory, particularly associative memory. In sum, the ingredients of our formula facilitate analysis and processing of information.

Increases energy level: As we established, high activity of dopamine is crucial for cognitive functions but it is not the only feature of this compound. Turns out that dopamine has an important role in regulating levels of energy – in both mental and physical sense. NALT and L-DOPA (obtained from Mucuna) are precursors of dopamine. St. John’s wort and Rhodiola support their activity and help those herbs to stay active for a longer time. It is worth mentioning that dopamine can get transformed into epinephrine and norepinephrine that act as excitatory neurotransmitters. Yet, our formula may help to feel more energetic by activating other mechanisms as well. Rhodiola stimulates bioelectric activity within the hippocampus which is a sign that the neurons of this brain structure work harder and positively affect memory. Ginkgo biloba and cinnamon cassia improve blood flow in the arteries that reach the brain so more oxygen and essential nutrients can be supplied to our “intellectual headquarters”. Moreover, St. John’s wort influences cellular efficiency by improving the functioning of mitochondria that produce energy (in the form of ATP) that is vital for all bodily cells to survive. Rhodiola has another unique feature – it improves tolerance to fatigue. Research indicates that it helps to maintain a high level of focus, short-term memory and quick reactions even if the person is tired. All these effects combined make this synergistic recipe a great support for cognitive endurance.