Supports the cardiovascular system: During studies with an animal model, Ligusticum was shown to extend the life of the nematode C. elegans. Certainly, the plant’s ability to protect against oxidative stress is of great importance here. This is because the active compounds of ligusticum increase the expression of antioxidant pathway genes and activate antioxidant enzymes. They may also delay the aging of smooth muscle cells – including those in blood vessels. In addition, the results show that gout improves blood flow. This is because it has an anticoagulant effect, reducing the number of platelets and inhibiting the aggregation of red blood cells. It also dilates blood vessels and lowers systolic as well as diastolic blood pressure. It also reduces cholesterol levels and prevents the formation of atherosclerotic plaques. All these properties mean that Ligusticum extract can help to improve cardiovascular health.

Supports liver and kidney health: Ligusticum chuanxiong can effectively support the body’s natural cleansing mechanisms. Most noteworthy in that regard are the antioxidant properties of this plant. The active compounds contained in it increase the activity of endogenous antioxidants, helping to neutralize free radicals efficiently. They also reduce the production of reactive oxygen species and inhibit lipid peroxidation. Besides that, they have a beneficial effect on the liver, which metabolizes substances that are potentially toxic to the body. During studies, it has been shown that this plant can alleviate liver damage caused by inflammation, but also prevent steatosis and fibrosis of this organ. The kidneys are equally important for detoxifying the body since they remove unnecessary metabolic products and toxins. Ligusticum regulates the levels of pro-inflammatory cytokines in these organs, thus protecting them from damage caused by inflammation. It reduces oxidative stress within them and restores the normal metabolic dynamics of mitochondria. Moreover, it supports and regulates the phagocytic function of renal tubule cells. In this way, ligusticum extract facilitates the body’s protection against toxins.

Nervous system protection: Antioxidant properties also underlie the beneficial effects of Ligusticum extract on the nervous system. Research results show that the active compounds of this plant can reduce the release of reactive oxygen species from microglia cells and counteract neuroinflammation. They also reduce damage to brain tissue caused by ischemia. They stabilize mitochondria and reduce the loss of hippocampal neurons. In addition, these compounds stimulate regeneration of the central nervous system – intensifying the movement of stem cells to damaged areas. They can also be part of the prevention of neurodegenerative diseases. This is because they protect neurons from the damaging effects of beta amyloid, and help to increase the activity of dopamine and acetylcholine – neurotransmitters important for cognitive abilities. The neuroprotective potential of Ligusticum makes this plant a valuable support for the nervous system.

Regulation of the immune system: Traditional Chinese Medicine recommends the use of Ligusticum root as a supportive agent for rheumatic ailments. Scientific results prove that the active compounds of this plant have a protective effect on joint cartilage. They prevent the death of its cells and protect them from inflammation. These compounds show an anti-inflammatory effect – they reduce the release of nitric oxide by macrophages. Besides that, they inhibit the activity of COX-1 and COX-2 enzymes – the same mechanism of action exhibited by non-steroidal anti-inflammatory drugs (NSAIDs). In addition, Ligusticum has an antipyretic effect. It regulates the activity of pyrogens and neurotransmitters in the hypothalamus, which affects the body’s thermoregulation. What’s more, this plant can support the body’s natural mechanisms of protection against the development of cancer. Thanks to its broad spectrum of action, Ligusticum is a valuable remedy that helps with inflammatory joint issues and much more.