IDRA-21 | AMPA-Diazine™

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IDRA-21 is a modern compound that significantly improves cognitive performance. It increases the activity of glutamate – the main stimulatory neurotransmitter. IDRA-21 supports attention, focus and the ability to assimilate new information. There have also been scientific reports indicating that this compound effectively improves mood.


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IDRA-21 | AMPA-Diazine™ description

Properties: Why is it that we are able to learn? To this day, it is not known in what form new information is saved in our memory exactly. However, processes that lead to that are quite well understood. 

First, our brain needs to be stimulated. Glutamate is a neurotransmitter that is responsible for this stimulation. Appropriate activity of glutamate results in the extension of the so-called working memory – memory area where new information is stored and where it is initially processed. IDRA-21 stimulates receptors for glutamate. That results in the increased activity of this neuromodulator and consequently brings improved mental capability. This is a little like furnishing our computer with one more RAM chip. 

Processed information is ready to be stored in the long-term memory. What promotes memory consolidation? Repetition. Remembering every new information results in the creation of a new “synaptic pathway”. By repeating new words several times, we activate the same connection between neurons again and again. That leads to its reinforcement – it is something like bench press for our pectoral muscles. Our brain can exercise the same way thanks to the process called the long-term potentiation (LTP). And this is where IDRA-21 comes into play again. It has been proven that it stimulates our central nervous system to repeatedly activate newly established synaptic connections. That leads to greater durability of saved information. 

So, now the data is processed and assimilated in a more efficient way. All that remains is to relax. It is still not known how it happens but research on IDRA-21, and other compounds that exhibit similar properties, provides a conclusion that they can effectively improve our mood. It is worth adding that IDRA-21 has neuroprotective properties. Not only does it facilitate acquisition of new information, it also helps to save everything properly so your precious data should not be lost somewhere in the middle.

Occurrence: IDRA-21 is not present in nature. Instead, it is obtained by laboratory synthesis. This synthetic compound was first developed by scientists in the 1990s.

Biochemistry: IDRA-21 is an organic chemical compound that belongs to the group of ampakines – compounds that increase the activity of glutamatergic AMPA receptors. It is a derivative of benzothiazine. It occurs in the form of two optical isomers (enantiomers) that differ in pharmacological properties. Only the dextrorotatory enantiomer (+)-IDRA-21 is biologically active. It easily crosses the blood-brain barrier. It increases the activity of the main stimulatory neurotransmitter –  glutamate – it acts as a positive allosteric modulator of AMPA receptors. It also contributes to the stimulation of long-term potentiation (LTP) within hippocampal neurons. LTP forms the basis of establishing new connections between neurons. That process is known as neurogenesis.

Fun fact: Effects of IDRA-21 activity in the human body are still being felt up to 48 hours after the last dose.

IDRA-21 | AMPA-Diazine™ benefits

Improves attention: Glutamate acts as the main stimulatory neurotransmitter. Its appropriate activity is essential for our ability to focus on any object. In addition, it determines working memory whose proper functioning is the foundation of the so-called multitasking, the ability to smoothly transfer attention from one object to another. It has been proven that IDRA-21 acts as the positive allosteric modulator of AMPA receptors that are activated by glutamate. It results in the improved activity of this neurotransmitter which supports concentration and working memory. Results of scientific studies and users’ opinion indicate that a single dose of this compound is sufficient to notice its activity. This effect lasts for up to 48 hours after the last dose.

Facilitates learning process: The long-term potentiation (LTP) is fundamental to the process of information and new skills acquisition. Its main mechanism relies on repetitive stimulation of target connections. Due to that, these connections are stronger and become consolidated. Then it is much easier to initialize this target neural pathway and use the skills that we learned. Scientific reports indicate that IDRA-21 stimulates LTP. That way, it makes it easier to establish new neural pathways and, in turn, to learn new things.

Improves intellectual capacity: Scientific analyses show that IDRA-21 has a positive impact on the functioning of the central nervous system. It may prevent the deterioration of cognitive skills by the action of some substances. There is evidence that this compound is able to reduce the impairment of operational efficiency caused by aging.

Supports good mood: Glutamate is a neurotransmitter important not only because of its positive effects on intellectual performance. Its proper activity is also essential for a good mood. Compounds that activate AMPA receptors have been extensively studied. Studies to date indicate that IDRA-21 can significantly improve our mood. This positive effect results from its ability to stimulate glutamate activity and to increase synaptic plasticity.

IDRA-21 | AMPA-Diazine™ product specification


  • powdered raw ingredient
  • IDRA-21 >99%; pharmaceutical quality
  • blue micro-spoon ~5 mg
  • airtight ALU-PET bag
  • nutrition, neuroregulation, herbal medicine
  • ingredient admitted to trading in the EU and the US

IDRA-21 | AMPA-Diazine™ usage


  • 5 – 10 mg
  • 1
  • without food
  • in the morning / during the day
  • 2-3 days a week

IDRA-21 | AMPA-Diazine™ stacking

To improve attention:
To facilitate information acquisition:
To increase energy level:
To improve mood:

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The above information about products should be considered a historical and scientific facts, not a recommendation on how to use a specific substance. Dietary supplements should not be treated as an alternative to a healthy lifestyle and balanced diet. The above information is not medical advice. Every use of a dietary supplement or herbal/nootropic compound should be consulted with a doctor or a specialist. Dietary supplements as well as nootropic and herbal compounds should not be mixed with medication. Our products should not be used by breastfeeding women and by the people under the age of 18.