IDRA-21 | AMPA-Diazine™

Properties: Why is it that we are able to learn? To this day, it is not known in what form new information is saved in our memory exactly. However, processes that lead to that are quite well understood. 

First, our brain needs to be stimulated. Glutamate is a neurotransmitter that is responsible for this stimulation. Appropriate activity of glutamate results in the extension of the so-called working memory – memory area where new information is stored and where it is initially processed. IDRA-21 stimulates receptors for glutamate. That results in the increased activity of this neuromodulator and consequently brings improved mental capability. This is a little like furnishing our computer with one more RAM chip. 

Processed information is ready to be stored in the long-term memory. What promotes memory consolidation? Repetition. Remembering every new information results in the creation of a new “synaptic pathway”. By repeating new words several times, we activate the same connection between neurons again and again. That leads to its reinforcement – it is something like bench press for our pectoral muscles. Our brain can exercise the same way thanks to the process called the long-term potentiation (LTP). And this is where IDRA-21 comes into play again. It has been proven that it stimulates our central nervous system to repeatedly activate newly established synaptic connections. That leads to greater durability of saved information. 

So, now the data is processed and assimilated in a more efficient way. All that remains is to relax. It is still not known how it happens but research on IDRA-21, and other compounds that exhibit similar properties, provides a conclusion that they can effectively improve our mood. It is worth adding that IDRA-21 has neuroprotective properties. Not only does it facilitate acquisition of new information, it also helps to save everything properly so your precious data should not be lost somewhere in the middle.

Occurrence: IDRA-21 is not present in nature. Instead, it is obtained by laboratory synthesis. This synthetic compound was first developed by scientists in the 1990s.

Biochemistry: IDRA-21 is an organic chemical compound that belongs to the group of ampakines – compounds that increase the activity of glutamatergic AMPA receptors. It is a derivative of benzothiazine. It occurs in the form of two optical isomers (enantiomers) that differ in pharmacological properties. Only the dextrorotatory enantiomer (+)-IDRA-21 is biologically active. It easily crosses the blood-brain barrier. It increases the activity of the main stimulatory neurotransmitter –  glutamate – it acts as a positive allosteric modulator of AMPA receptors. It also contributes to the stimulation of long-term potentiation (LTP) within hippocampal neurons. LTP forms the basis of establishing new connections between neurons. That process is known as neurogenesis.

Fun fact: Effects of IDRA-21 activity in the human body are still being felt up to 48 hours after the last dose.